A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 lg mL1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.
Girt GC, Mahindra A, Al Jabri ZJH, De Ste Croix M, Oggioni MR, Jamieson AG (2018). Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus. CHEMICAL COMMUNICATIONS, 54(22), 2767-2770 [10.1039/c7cc06093a].
Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus
Oggioni MR;
2018
Abstract
A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 lg mL1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
