A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 lg mL1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.
Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus / Girt GC; Mahindra A; Al Jabri ZJH; De Ste Croix M; Oggioni MR; Jamieson AG. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 54:22(2018), pp. 2767-2770. [10.1039/c7cc06093a]
Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus
Oggioni MR;
2018
Abstract
A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1–6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 lg mL1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
