In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies.
Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions / Pancrazzi F.; Sarti N.; Mazzeo P.P.; Bacchi A.; Carfagna C.; Mancuso R.; Gabriele B.; Costa M.; Stirling A.; Della Ca' N.. - In: ORGANIC LETTERS. - ISSN 1523-7052. - ELETTRONICO. - 22:4(2020), pp. 1569-1574. [10.1021/acs.orglett.0c00171]
Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
Carfagna C.;
2020
Abstract
In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies.| File | Dimensione | Formato | |
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