Several bisphosphonates bearing a substituted isoxazolidine ring have been synthesized in good yield by direct 1,3-dipolar cyclization reaction, under microwaves catalysis, in the absence of solvent. The method allows the simultaneous incorporation, on the geminal position of the bisphosphonate framework, of a basic nitrogen and of an oxygen atom, as third hook. Hydrophobicity-hydrophilicity of BPs is discussed with the help of distribution coefficients. © 2011 Elsevier Ltd.

Bortolini O., Mulani I., De Nino A., Maiuolo L., Nardi M., Russo B., et al. (2011). Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions. TETRAHEDRON, 67(31), 5635-5641 [10.1016/j.tet.2011.05.098].

Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions

Russo B.;Avnet S.
2011

Abstract

Several bisphosphonates bearing a substituted isoxazolidine ring have been synthesized in good yield by direct 1,3-dipolar cyclization reaction, under microwaves catalysis, in the absence of solvent. The method allows the simultaneous incorporation, on the geminal position of the bisphosphonate framework, of a basic nitrogen and of an oxygen atom, as third hook. Hydrophobicity-hydrophilicity of BPs is discussed with the help of distribution coefficients. © 2011 Elsevier Ltd.
2011
Bortolini O., Mulani I., De Nino A., Maiuolo L., Nardi M., Russo B., et al. (2011). Efficient synthesis of isoxazolidine-substituted bisphosphonates by 1,3-dipolar cycloaddition reactions. TETRAHEDRON, 67(31), 5635-5641 [10.1016/j.tet.2011.05.098].
Bortolini O.; Mulani I.; De Nino A.; Maiuolo L.; Nardi M.; Russo B.; Avnet S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/796790
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