In this study, we report the fabrication of two different three-dimensional (3D) architectures of regenerated silk (RS) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with embedded functionalities. 3D printed cylinders with an internal layer of PHBV and an external of calcium ions (Ca++) or potassium nitrate (KNO3) modified RS were designed to control the radial shrinkage, water uptake and compression strength. Such cylinders were then used as sutureless thermoresponsive clips, measuring the bursting resistance once applied on an anastomized porcine intestine. Experimental data are supported by finite element simulations that model the tube contraction, demonstrating the possibility to program the shape-changing behavior of 3D printed structures. Printing RS on PHBV, we obtained responsive 3D grids to external force with self-powering properties. The synergic effect obtained by combining materials on appropriate architectures paves the way to potential clinical applications ranging from monitoring of vital signs to sutureless sealant patches.

Bittolo Bon, S., Chiesa, I., Morselli, D., Degli Esposti, M., Fabbri, P., De Maria, C., et al. (2021). Printable smart 3D architectures of regenerated silk on poly(3-hydroxybutyrate-co-3-hydroxyvalerate). MATERIALS & DESIGN, 201, 1-9 [10.1016/j.matdes.2021.109492].

Printable smart 3D architectures of regenerated silk on poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Morselli, Davide;Degli Esposti, Micaela;Fabbri, Paola;
2021

Abstract

In this study, we report the fabrication of two different three-dimensional (3D) architectures of regenerated silk (RS) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with embedded functionalities. 3D printed cylinders with an internal layer of PHBV and an external of calcium ions (Ca++) or potassium nitrate (KNO3) modified RS were designed to control the radial shrinkage, water uptake and compression strength. Such cylinders were then used as sutureless thermoresponsive clips, measuring the bursting resistance once applied on an anastomized porcine intestine. Experimental data are supported by finite element simulations that model the tube contraction, demonstrating the possibility to program the shape-changing behavior of 3D printed structures. Printing RS on PHBV, we obtained responsive 3D grids to external force with self-powering properties. The synergic effect obtained by combining materials on appropriate architectures paves the way to potential clinical applications ranging from monitoring of vital signs to sutureless sealant patches.
2021
Bittolo Bon, S., Chiesa, I., Morselli, D., Degli Esposti, M., Fabbri, P., De Maria, C., et al. (2021). Printable smart 3D architectures of regenerated silk on poly(3-hydroxybutyrate-co-3-hydroxyvalerate). MATERIALS & DESIGN, 201, 1-9 [10.1016/j.matdes.2021.109492].
Bittolo Bon, Silvia; Chiesa, Irene; Morselli, Davide; Degli Esposti, Micaela; Fabbri, Paola; De Maria, Carmelo; Foggi Viligiardi, Tommaso; Morabito, A...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/794566
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