Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models / Rossi A.; Rigotto G.; Valente G.; Giorgio V.; Basso E.; Filadi R.; Pizzo P.. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - 30:7(2020), pp. 2332-2348. [10.1016/j.celrep.2020.01.060]

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models

Giorgio V.;
2020

Abstract

Mitochondria are key organelles for brain health. Rossi et al. show that, in different Alzheimer's disease cell models, lower mitochondrial Ca2+ signal and pyruvate uptake reduce ATP synthesis. GSK-3β hyper-activation contributes to the defect by impairing HK1-mitochondria association, decreasing MPC2 levels and destabilizing MPC complexes. Defective bioenergetics affects neuronal functionality.
2020
Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models / Rossi A.; Rigotto G.; Valente G.; Giorgio V.; Basso E.; Filadi R.; Pizzo P.. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - 30:7(2020), pp. 2332-2348. [10.1016/j.celrep.2020.01.060]
Rossi A.; Rigotto G.; Valente G.; Giorgio V.; Basso E.; Filadi R.; Pizzo P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/794430
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