Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca2+ release. Transient openings may be involved in physiological Ca2+ homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca2+ can reversibly switch this energy-conserving nanomachine into an energy-dissipating device.

Calcium and regulation of the mitochondrial permeability transition / Giorgio V.; Guo L.; Bassot C.; Petronilli V.; Bernardi P.. - In: CELL CALCIUM. - ISSN 0143-4160. - ELETTRONICO. - 70:(2018), pp. 56-63. [10.1016/j.ceca.2017.05.004]

Calcium and regulation of the mitochondrial permeability transition

Giorgio V.
Primo
;
2018

Abstract

Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca2+ release. Transient openings may be involved in physiological Ca2+ homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca2+ can reversibly switch this energy-conserving nanomachine into an energy-dissipating device.
2018
Calcium and regulation of the mitochondrial permeability transition / Giorgio V.; Guo L.; Bassot C.; Petronilli V.; Bernardi P.. - In: CELL CALCIUM. - ISSN 0143-4160. - ELETTRONICO. - 70:(2018), pp. 56-63. [10.1016/j.ceca.2017.05.004]
Giorgio V.; Guo L.; Bassot C.; Petronilli V.; Bernardi P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/794428
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