Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.

Von Stockum S., Giorgio V., Trevisan E., Lippe G., Glick G.D., Forte M.A., et al. (2015). F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 290(8), 4537-4544 [10.1074/jbc.C114.629766].

F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Giorgio V.;
2015

Abstract

Background: The Ca2+-induced Ca2+ release channel (mCrC) of Drosophila mitochondria is similar to the permeability transition pore (PTP). Results: mCrC is modulated by PTP effectors and Drosophila F-ATPase forms 53-pS channels. Conclusion: F-ATPase mediates Ca2+-induced Ca2+ release in Drosophila mitochondria. Significance: Channel formation by F-ATPases has been conserved in evolution, but species-specific features exist that may underscore different roles in different organisms.
2015
Von Stockum S., Giorgio V., Trevisan E., Lippe G., Glick G.D., Forte M.A., et al. (2015). F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 290(8), 4537-4544 [10.1074/jbc.C114.629766].
Von Stockum S.; Giorgio V.; Trevisan E.; Lippe G.; Glick G.D.; Forte M.A.; Da-Re C.; Checchetto V.; Mazzotta G.; Costa R.; Szabo I.; Bernardi P.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/794370
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 60
social impact