Background: A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn's disease (CD) patients. Hence, we evaluated, for the first time, the performance of this novel CE and the add-on value of the 344°-viewing in a multi-center real-life setting. Methods: Consecutive patients with suspected or established CD received the PillCam™ Crohn's System as supplementary diagnostic work-up focused on the small-bowel between June 2017 and June 2018. Technical and clinical data, including the panenteric CE diagnostic yield, the Lewis score and the impact of small-bowel findings on clinical management during a 6-months follow-up (new diagnosis, staging or treatment upgrade) were collected, thereby evaluating the added value of the 344° panoramic-view (lesions detected by camera A and B) over the standard 172°-view (lesions detected by one camera only). Results: Among 41 patients (aged 43 ± 20 years), 73% underwent CE for suspected CD and 27% for established CD. The rate of complete enteroscopy was 90%. No technical failure or retention occurred. Compared to the standard 172° view, the panoramic 344°-view revealed a greater number of patients with a relevant lesion (56.1% vs. 39.0%; P = 0.023), resulting in higher Lewis score (222,8 vs. 185.7; P = 0.031), and improved clinical management (48.8% vs. 31.7%, P = 0.023). Conclusions: The panoramic 344°-view increases small-bowel CE accuracy, thereby improving the clinical management of CD patients with mild small-bowel active disease. This system should be regarded as a new standard for both small-bowel diagnosis and monitoring in inflammatory bowel diseases.

Usefulness of panoramic 344°-viewing in Crohn's disease capsule endoscopy: A proof of concept pilot study with the novel PillCam™ Crohn's system / Tontini G.E.; Rizzello F.; Cavallaro F.; Bonitta G.; Gelli D.; Pastorelli L.; Salice M.; Vecchi M.; Gionchetti P.; Calabrese C.. - In: BMC GASTROENTEROLOGY. - ISSN 1471-230X. - ELETTRONICO. - 20:1(2020), pp. 97.1-97.6. [10.1186/s12876-020-01231-0]

Usefulness of panoramic 344°-viewing in Crohn's disease capsule endoscopy: A proof of concept pilot study with the novel PillCam™ Crohn's system

Rizzello F.
Membro del Collaboration Group
;
Gelli D.
Membro del Collaboration Group
;
Salice M.
Membro del Collaboration Group
;
Gionchetti P.
Membro del Collaboration Group
;
Calabrese C.
Ultimo
Writing – Original Draft Preparation
2020

Abstract

Background: A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn's disease (CD) patients. Hence, we evaluated, for the first time, the performance of this novel CE and the add-on value of the 344°-viewing in a multi-center real-life setting. Methods: Consecutive patients with suspected or established CD received the PillCam™ Crohn's System as supplementary diagnostic work-up focused on the small-bowel between June 2017 and June 2018. Technical and clinical data, including the panenteric CE diagnostic yield, the Lewis score and the impact of small-bowel findings on clinical management during a 6-months follow-up (new diagnosis, staging or treatment upgrade) were collected, thereby evaluating the added value of the 344° panoramic-view (lesions detected by camera A and B) over the standard 172°-view (lesions detected by one camera only). Results: Among 41 patients (aged 43 ± 20 years), 73% underwent CE for suspected CD and 27% for established CD. The rate of complete enteroscopy was 90%. No technical failure or retention occurred. Compared to the standard 172° view, the panoramic 344°-view revealed a greater number of patients with a relevant lesion (56.1% vs. 39.0%; P = 0.023), resulting in higher Lewis score (222,8 vs. 185.7; P = 0.031), and improved clinical management (48.8% vs. 31.7%, P = 0.023). Conclusions: The panoramic 344°-view increases small-bowel CE accuracy, thereby improving the clinical management of CD patients with mild small-bowel active disease. This system should be regarded as a new standard for both small-bowel diagnosis and monitoring in inflammatory bowel diseases.
2020
Usefulness of panoramic 344°-viewing in Crohn's disease capsule endoscopy: A proof of concept pilot study with the novel PillCam™ Crohn's system / Tontini G.E.; Rizzello F.; Cavallaro F.; Bonitta G.; Gelli D.; Pastorelli L.; Salice M.; Vecchi M.; Gionchetti P.; Calabrese C.. - In: BMC GASTROENTEROLOGY. - ISSN 1471-230X. - ELETTRONICO. - 20:1(2020), pp. 97.1-97.6. [10.1186/s12876-020-01231-0]
Tontini G.E.; Rizzello F.; Cavallaro F.; Bonitta G.; Gelli D.; Pastorelli L.; Salice M.; Vecchi M.; Gionchetti P.; Calabrese C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/792814
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