Glanzmann's thrombasthenia (GT) is a rare familial thrombocytic disease inherited as an autosomal recessive disorder that can induce hemorrhages due to a defect of platelet aggregation, resulting from the absence or reduced concentration of the membrane glycoproteic receptor binding the fibrinogen (integrin α(IIb)β3). The gastrointestinal tract is the site of bleeding in only about 10% of cases but the related mortality is high (12.8%) (Table 2). Among the deaths due to hemorrhage, digestive bleeding causes 57.1%. According to reported data, the source of bleeding may be from preexisting gastroduodenal chronic and acute lesions. We report a case of severe and relapsing upper digestive bleeding in a woman with GT and coexisting thrombocytopenia (from HCV-related liver cirrhosis) and H. pylori-positive duodenal ulcer.

Calabrese C., Di Febo G., Areni A., Morelli M.C., Scialpi C., Brandi G., et al. (2000). Severe and relapsing upper gastrointestinal bleeding in a patient with Glanzmann's thrombasthenia. DIGESTIVE DISEASES AND SCIENCES, 45(3), 633-636 [10.1023/A:1005478114897].

Severe and relapsing upper gastrointestinal bleeding in a patient with Glanzmann's thrombasthenia

Calabrese C.
Primo
Writing – Original Draft Preparation
;
Di Febo G.;Scialpi C.;Brandi G.;
2000

Abstract

Glanzmann's thrombasthenia (GT) is a rare familial thrombocytic disease inherited as an autosomal recessive disorder that can induce hemorrhages due to a defect of platelet aggregation, resulting from the absence or reduced concentration of the membrane glycoproteic receptor binding the fibrinogen (integrin α(IIb)β3). The gastrointestinal tract is the site of bleeding in only about 10% of cases but the related mortality is high (12.8%) (Table 2). Among the deaths due to hemorrhage, digestive bleeding causes 57.1%. According to reported data, the source of bleeding may be from preexisting gastroduodenal chronic and acute lesions. We report a case of severe and relapsing upper digestive bleeding in a woman with GT and coexisting thrombocytopenia (from HCV-related liver cirrhosis) and H. pylori-positive duodenal ulcer.
2000
Calabrese C., Di Febo G., Areni A., Morelli M.C., Scialpi C., Brandi G., et al. (2000). Severe and relapsing upper gastrointestinal bleeding in a patient with Glanzmann's thrombasthenia. DIGESTIVE DISEASES AND SCIENCES, 45(3), 633-636 [10.1023/A:1005478114897].
Calabrese C.; Di Febo G.; Areni A.; Morelli M.C.; Scialpi C.; Brandi G.; Miglioli M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/792087
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