Dear Editor, Acute myeloid leukemia (AML) patients carrying complex karyotype or aneuploidies have a very poor prognosis, with a 5-year overall survival (OS) <20%1. We and others have shown that these patients are characterized by high genomic instability, along with defects of DNA damage response (DDR) genes2,3.

Padella A., Fontana M.C., Marconi G., Fonzi E., Petracci E., Ferrari A., et al. (2021). Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway. BLOOD CANCER JOURNAL, 11(1), 7-28 [10.1038/s41408-020-00396-x].

Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway

Padella A.;Fontana M. C.;Marconi G.;Fonzi E.;Petracci E.;Baldazzi C.;Papayannidis C.;Testoni N.;Castellani G.;
2021

Abstract

Dear Editor, Acute myeloid leukemia (AML) patients carrying complex karyotype or aneuploidies have a very poor prognosis, with a 5-year overall survival (OS) <20%1. We and others have shown that these patients are characterized by high genomic instability, along with defects of DNA damage response (DDR) genes2,3.
2021
Padella A., Fontana M.C., Marconi G., Fonzi E., Petracci E., Ferrari A., et al. (2021). Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway. BLOOD CANCER JOURNAL, 11(1), 7-28 [10.1038/s41408-020-00396-x].
Padella A.; Fontana M.C.; Marconi G.; Fonzi E.; Petracci E.; Ferrari A.; Baldazzi C.; Papayannidis C.; Ghelli Luserna Di Rora A.; Testoni N.; Castella...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/790463
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