Dear Editor, Acute myeloid leukemia (AML) patients carrying complex karyotype or aneuploidies have a very poor prognosis, with a 5-year overall survival (OS) <20%1. We and others have shown that these patients are characterized by high genomic instability, along with defects of DNA damage response (DDR) genes2,3.
Padella A., Fontana M.C., Marconi G., Fonzi E., Petracci E., Ferrari A., et al. (2021). Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway. BLOOD CANCER JOURNAL, 11(1), 7-28 [10.1038/s41408-020-00396-x].
Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway
Padella A.;Fontana M. C.;Marconi G.;Fonzi E.;Petracci E.;Baldazzi C.;Papayannidis C.;Testoni N.;Castellani G.;
2021
Abstract
Dear Editor, Acute myeloid leukemia (AML) patients carrying complex karyotype or aneuploidies have a very poor prognosis, with a 5-year overall survival (OS) <20%1. We and others have shown that these patients are characterized by high genomic instability, along with defects of DNA damage response (DDR) genes2,3.File in questo prodotto:
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