BACKGROUND.: Head and neck squamous cell carcinomas (SCCs) are among the most aggressive types of cancer. The Simian virus 40 (SV40), which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human pleomorphic adenoma in the parotid gland. The aim of this study was to evaluate the presence of SV40 and 2 human polyomaviruses-BK virus (BKV) and JC virus (JCV)-in a large sample of SCCs of the oral cavity. METHODS.: Quantitative real-time polymerase chain reaction (PCR) was used to evaluate virus load. RESULTS.: Overall, the prevalence of SV40, BKV, and JCV in oral SCC was negligible. Matched-pair case-control analysis indicated that prevalence among the controls did not significantly differ with respect to analyzed cases. CONCLUSION.: The results did not indicate a major role for SV40, BKV, and JCV in the etiology of oral SCC.
Palmieri A., Carinci F., Martinelli M., Spinelli G., Lo Muzio L., Rubini C., et al. (2010). Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity. HEAD & NECK, 32(3), 375-380 [10.1002/hed.21197].
Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity
PALMIERI, ANNALISA;MARTINELLI, MARCELLA;SCAPOLI, LUCA
2010
Abstract
BACKGROUND.: Head and neck squamous cell carcinomas (SCCs) are among the most aggressive types of cancer. The Simian virus 40 (SV40), which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human pleomorphic adenoma in the parotid gland. The aim of this study was to evaluate the presence of SV40 and 2 human polyomaviruses-BK virus (BKV) and JC virus (JCV)-in a large sample of SCCs of the oral cavity. METHODS.: Quantitative real-time polymerase chain reaction (PCR) was used to evaluate virus load. RESULTS.: Overall, the prevalence of SV40, BKV, and JCV in oral SCC was negligible. Matched-pair case-control analysis indicated that prevalence among the controls did not significantly differ with respect to analyzed cases. CONCLUSION.: The results did not indicate a major role for SV40, BKV, and JCV in the etiology of oral SCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.