Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.
Tortorella S., Maturi M., Dapporto F., Spanu C., Sambri L., Comes Franchini M., et al. (2020). Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics. CELLULOSE, 27, 8503-8511 [10.1007/s10570-020-03390-5].
Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics
Tortorella S.;Maturi M.;Spanu C.;Sambri L.;Comes Franchini M.;Locatelli E.
2020
Abstract
Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.| File | Dimensione | Formato | |
|---|---|---|---|
|
Manuscript_Revision_Cellulose_ComesFranchini (1).pdf
accesso aperto
Tipo:
Postprint
Licenza:
Licenza per accesso libero gratuito
Dimensione
1.71 MB
Formato
Adobe PDF
|
1.71 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
