Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.

Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics / Tortorella S.; Maturi M.; Dapporto F.; Spanu C.; Sambri L.; Comes Franchini M.; Chiariello M.; Locatelli E.. - In: CELLULOSE. - ISSN 0969-0239. - ELETTRONICO. - 27:(2020), pp. 8503-8511. [10.1007/s10570-020-03390-5]

Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics

Tortorella S.;Maturi M.;Spanu C.;Sambri L.;Comes Franchini M.;Locatelli E.
2020

Abstract

Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.
2020
Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics / Tortorella S.; Maturi M.; Dapporto F.; Spanu C.; Sambri L.; Comes Franchini M.; Chiariello M.; Locatelli E.. - In: CELLULOSE. - ISSN 0969-0239. - ELETTRONICO. - 27:(2020), pp. 8503-8511. [10.1007/s10570-020-03390-5]
Tortorella S.; Maturi M.; Dapporto F.; Spanu C.; Sambri L.; Comes Franchini M.; Chiariello M.; Locatelli E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/788419
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