Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.
Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics / Tortorella S.; Maturi M.; Dapporto F.; Spanu C.; Sambri L.; Comes Franchini M.; Chiariello M.; Locatelli E.. - In: CELLULOSE. - ISSN 0969-0239. - ELETTRONICO. - 27:(2020), pp. 8503-8511. [10.1007/s10570-020-03390-5]
Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics
Tortorella S.;Maturi M.;Spanu C.;Sambri L.;Comes Franchini M.;Locatelli E.
2020
Abstract
Herein we report the synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent.The carbamate linkage present in the linker, shows stability in aqueous environments for a wide range of conditions and can only be hydrolyzed in the presence of cells, freeing the active drug, with unmodified chemotherapeutic properties.| File | Dimensione | Formato | |
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