The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.
Sicignano M., Rodriguez R.I., Capaccio V., Borello F., Cano R., De Riccardis F., et al. (2020). Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis. ORGANIC & BIOMOLECULAR CHEMISTRY, 18, 2914-2920 [10.1039/d0ob00476f].
Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis
Bernardi L.;
2020
Abstract
The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.File in questo prodotto:
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