Herein is reported the asymmetric allylic benzylation of Morita-Baylis-Hillman (MBH) carbonates with 2-methylbenzophenone (MBP) derivatives as nonstabilized photogenerated C-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of the nucleophile, enables the stereoselective installation of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.
Light-Triggered Catalytic Asymmetric Allylic Benzylation with Photogenerated C-Nucleophiles / Paria S.; Carletti E.; Marcon M.; Cherubini-Celli A.; Mazzanti A.; Rancan M.; Dell'amico L.; Bonchio M.; Companyo X.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 85:6(2020), pp. 4463-4474. [10.1021/acs.joc.0c00175]
Light-Triggered Catalytic Asymmetric Allylic Benzylation with Photogenerated C-Nucleophiles
Mazzanti A.;
2020
Abstract
Herein is reported the asymmetric allylic benzylation of Morita-Baylis-Hillman (MBH) carbonates with 2-methylbenzophenone (MBP) derivatives as nonstabilized photogenerated C-nucleophiles. The dual activation of both reaction partners, chiral Lewis-base activation of the electrophile and light activation of the nucleophile, enables the stereoselective installation of benzyl groups at the allylic position to forge tertiary and quaternary carbon centers.| File | Dimensione | Formato | |
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