Ileal Peyer's patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas.
MARRUCHELLA G., | LIGIOS C., | BAFFONI M.|, CANCEDDA M.G., | DEMONTIS F., | DONATUCCI G., et al. (2009). Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines. ARCHIVES OF VIROLOGY, 154/4, 709-714 [10.1007/s00705-009-0361-5].
Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines
CHIOCCHETTI, ROBERTO;CLAVENZANI, PAOLO;LALATTA COSTERBOSA, GIOVANNA;
2009
Abstract
Ileal Peyer's patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
