Ileal Peyer's patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas.
Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines / MARRUCHELLA G.;| LIGIOS C.;| BAFFONI M.|; CANCEDDA M.G.;| DEMONTIS F.;| DONATUCCI G.;| CHIOCCHETTI R.;| CLAVENZANI P.; LALATTA-COSTERBOSA G.;|DI GUARDO G.. - In: ARCHIVES OF VIROLOGY. - ISSN 0304-8608. - STAMPA. - 154/4:(2009), pp. 709-714. [10.1007/s00705-009-0361-5]
Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines
CHIOCCHETTI, ROBERTO;CLAVENZANI, PAOLO;LALATTA COSTERBOSA, GIOVANNA;
2009
Abstract
Ileal Peyer's patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
