A randomized two-arm prospective study was planned to assess the role of therapeutic drug monitoring (TDM) coupled with a Bayesian approach in tailoring vancomycin dosages in unstable critically ill patients. Group A (n=16) had their regimen adjusted day-by-day according to TDM and Bayesian forecasting (Da); group B (n=16) had their regimen adjusted day-by-day according to Moellering's nomogram (DM). Blood samples were collected every 1-2 days to assess the trough and peak plasma concentrations. In group A, the tailored Da required for optimizing vancomycin exposure were considerably higher than the DM in 7/16 cases, and lower than the DM in 1/16 cases. In group B, standard DM caused under-treatment in 3/16 cases and over-treatment in 4/16 cases. Most of these patients concomitantly had some conditions that might have altered vancomycin disposition. The TDM-guided Bayesian-based approach should be considered an invaluable tool for clinicians to handle appropriately on real-time vancomycin therapy in critically ill patients. © 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

TDM coupled with Bayesian forecasting should be considered an invaluable tool for optimizing vancomycin daily exposure in unstable critically ill patients / Pea F.; Bertolissi M.; Di Silvestre A.; Poz D.; Giordano F.; Furlanut M.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - ELETTRONICO. - 20:5(2002), pp. 326-332. [10.1016/S0924-8579(02)00188-7]

TDM coupled with Bayesian forecasting should be considered an invaluable tool for optimizing vancomycin daily exposure in unstable critically ill patients

Pea F.;
2002

Abstract

A randomized two-arm prospective study was planned to assess the role of therapeutic drug monitoring (TDM) coupled with a Bayesian approach in tailoring vancomycin dosages in unstable critically ill patients. Group A (n=16) had their regimen adjusted day-by-day according to TDM and Bayesian forecasting (Da); group B (n=16) had their regimen adjusted day-by-day according to Moellering's nomogram (DM). Blood samples were collected every 1-2 days to assess the trough and peak plasma concentrations. In group A, the tailored Da required for optimizing vancomycin exposure were considerably higher than the DM in 7/16 cases, and lower than the DM in 1/16 cases. In group B, standard DM caused under-treatment in 3/16 cases and over-treatment in 4/16 cases. Most of these patients concomitantly had some conditions that might have altered vancomycin disposition. The TDM-guided Bayesian-based approach should be considered an invaluable tool for clinicians to handle appropriately on real-time vancomycin therapy in critically ill patients. © 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
2002
TDM coupled with Bayesian forecasting should be considered an invaluable tool for optimizing vancomycin daily exposure in unstable critically ill patients / Pea F.; Bertolissi M.; Di Silvestre A.; Poz D.; Giordano F.; Furlanut M.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - ELETTRONICO. - 20:5(2002), pp. 326-332. [10.1016/S0924-8579(02)00188-7]
Pea F.; Bertolissi M.; Di Silvestre A.; Poz D.; Giordano F.; Furlanut M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/780461
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