The epithelial and mesenchymal cells involved in early embryonic facial development are guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and fusion of the frontonasal and maxillary processes could result in orofacial clefts that represent the most common craniofacial malformations in humans. The rarest and, probably for this reason, the least studied form of cleft involves only the secondary palate, which is posterior to the incisive foramen. The etiology of cleft palate only is multifactorial and involves both genetic and environmental risk factors. The intention of this review is to give the reader an overview of the efforts made by researchers to shed light on the underlying causes of this birth defect. Most of the scientific papers suggesting potential environmental and genetic causes of non-syndromic cleft palate are summarized in this review, including genome-wide association and gene–environment interaction studies.

Martinelli, M., Palmieri, A., Carinci, F., Scapoli, L. (2020). Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8, 1-21 [10.3389/fcell.2020.592271].

Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

Martinelli, Marcella
;
Palmieri, Annalisa;Scapoli, Luca
2020

Abstract

The epithelial and mesenchymal cells involved in early embryonic facial development are guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and fusion of the frontonasal and maxillary processes could result in orofacial clefts that represent the most common craniofacial malformations in humans. The rarest and, probably for this reason, the least studied form of cleft involves only the secondary palate, which is posterior to the incisive foramen. The etiology of cleft palate only is multifactorial and involves both genetic and environmental risk factors. The intention of this review is to give the reader an overview of the efforts made by researchers to shed light on the underlying causes of this birth defect. Most of the scientific papers suggesting potential environmental and genetic causes of non-syndromic cleft palate are summarized in this review, including genome-wide association and gene–environment interaction studies.
2020
Martinelli, M., Palmieri, A., Carinci, F., Scapoli, L. (2020). Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8, 1-21 [10.3389/fcell.2020.592271].
Martinelli, Marcella; Palmieri, Annalisa; Carinci, Francesco; Scapoli, Luca
File in questo prodotto:
File Dimensione Formato  
fcell-08-592271.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 445.15 kB
Formato Adobe PDF
445.15 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/779384
Citazioni
  • ???jsp.display-item.citation.pmc??? 27
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 48
social impact