ScCO2 foaming, a technology that enables the obtainment of porous scaffolds free of residual toxic solvent, is very a promising technique in tissue engineering. Unlike amorphous polymer foaming, application of this technology to semicrystalline polymers is complex, owing to limited diffusion of scCO2 in the crystal phase. This work presents the optimization of the foaming process of a highly crystalline random copolyester of w-pentadecalactone and e-caprolactone and the effect of foaming process parameters on 3D structure was investigated by Micro X-ray Computed Tomography.The obtained scaffolds possess mechanical properties matching those required for applications in cartilage tissue regeneration.
C. Gualandi, L. White, R. Gross, M. Scandola, K. Shakesheff, S. Howdle (2009). SUPERCRITICAL CARBON DIOXIDE FOAMING OF A HIGHLY CRYSTALLINE POLYESTER FOR TISSUE ENGINEERING APPLICATIONS. PISA : Pacini Editore.
SUPERCRITICAL CARBON DIOXIDE FOAMING OF A HIGHLY CRYSTALLINE POLYESTER FOR TISSUE ENGINEERING APPLICATIONS
GUALANDI, CHIARA;SCANDOLA, MARIASTELLA;
2009
Abstract
ScCO2 foaming, a technology that enables the obtainment of porous scaffolds free of residual toxic solvent, is very a promising technique in tissue engineering. Unlike amorphous polymer foaming, application of this technology to semicrystalline polymers is complex, owing to limited diffusion of scCO2 in the crystal phase. This work presents the optimization of the foaming process of a highly crystalline random copolyester of w-pentadecalactone and e-caprolactone and the effect of foaming process parameters on 3D structure was investigated by Micro X-ray Computed Tomography.The obtained scaffolds possess mechanical properties matching those required for applications in cartilage tissue regeneration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
