The proline-catalysed asymmetric aldol reaction is usually carried out in highly dipolar aprotic solvents (dimethylsulfoxide, dimethylformamide, acetonitrile) where proline presents an acceptable solubility. Protic solvents are generally characterized by poor stereocontrol (e.g., methanol) or poor reactivity (e.g., water). Here, we report that water/methanol mixtures are exceptionally simple and effective reaction media for the intermolecular organocatalytic aldol reaction using the simple proline as the catalyst.

Emma M.G., Tamburrini A., Martinelli A., Lombardo M., Quintavalla A., Trombini C. (2020). A simple and efficient protocol for proline-catalysed asymmetric aldol reaction. CATALYSTS, 10(6), 1-22 [10.3390/catal10060649].

A simple and efficient protocol for proline-catalysed asymmetric aldol reaction

Emma M. G.;Martinelli A.;Lombardo M.
;
Quintavalla A.
;
Trombini C.
2020

Abstract

The proline-catalysed asymmetric aldol reaction is usually carried out in highly dipolar aprotic solvents (dimethylsulfoxide, dimethylformamide, acetonitrile) where proline presents an acceptable solubility. Protic solvents are generally characterized by poor stereocontrol (e.g., methanol) or poor reactivity (e.g., water). Here, we report that water/methanol mixtures are exceptionally simple and effective reaction media for the intermolecular organocatalytic aldol reaction using the simple proline as the catalyst.
2020
Emma M.G., Tamburrini A., Martinelli A., Lombardo M., Quintavalla A., Trombini C. (2020). A simple and efficient protocol for proline-catalysed asymmetric aldol reaction. CATALYSTS, 10(6), 1-22 [10.3390/catal10060649].
Emma M.G.; Tamburrini A.; Martinelli A.; Lombardo M.; Quintavalla A.; Trombini C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/778323
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