We recently showed that a polymorphism in the fat mass and obesity associated (FTO) gene (AM931150: g.276T > G) is associated with fat deposition traits in pigs. To confirm this result, we genotyped this polymorphism in an Italian Duroc population made up by 313 performance tested pigs with known estimated breeding values (EBVs) for average daily gain, back fat thickness (BFT), feed:gain ratio, lean cuts (LC), and visible intermuscular fat (VIF, a measure of intermuscular fat in the hams). In addition, we genotyped 148 commercial heavy pigs for which several fat deposition traits and lean meat percentage were measured. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits (VIF, BFT and LC) in the Italian Duroc pigs (P < 0.01) and in the commercial pigs (intramuscular fat content of different muscles, P < 0.05 or P < 0.10; lean meat content, P < 0.05; BFT, P < 0.05; intermuscular fat content in the hams, P < 0.05).

Fontanesi L., Scotti E., Buttazzoni L., Dall'Olio S., Bagnato A., Lo Fiego D.P., et al. (2010). Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs. MOLECULAR BIOLOGY REPORTS, 37, 461-466 [10.1007/s11033-009-9638-8].

Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs

FONTANESI, LUCA;SCOTTI, EMILIO;DALL'OLIO, STEFANIA;DAVOLI, ROBERTA;RUSSO, VINCENZO
2010

Abstract

We recently showed that a polymorphism in the fat mass and obesity associated (FTO) gene (AM931150: g.276T > G) is associated with fat deposition traits in pigs. To confirm this result, we genotyped this polymorphism in an Italian Duroc population made up by 313 performance tested pigs with known estimated breeding values (EBVs) for average daily gain, back fat thickness (BFT), feed:gain ratio, lean cuts (LC), and visible intermuscular fat (VIF, a measure of intermuscular fat in the hams). In addition, we genotyped 148 commercial heavy pigs for which several fat deposition traits and lean meat percentage were measured. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits (VIF, BFT and LC) in the Italian Duroc pigs (P < 0.01) and in the commercial pigs (intramuscular fat content of different muscles, P < 0.05 or P < 0.10; lean meat content, P < 0.05; BFT, P < 0.05; intermuscular fat content in the hams, P < 0.05).
2010
Fontanesi L., Scotti E., Buttazzoni L., Dall'Olio S., Bagnato A., Lo Fiego D.P., et al. (2010). Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs. MOLECULAR BIOLOGY REPORTS, 37, 461-466 [10.1007/s11033-009-9638-8].
Fontanesi L.; Scotti E.; Buttazzoni L.; Dall'Olio S.; Bagnato A.; Lo Fiego D.P.; Davoli R.; Russo V.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/77812
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 46
  • ???jsp.display-item.citation.isi??? 42
social impact