Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has become established. The proliferation signal inhibitors everolimus and sirolimus have potent immunosuppressive and antiproliferative actions, with the potential to alter the natural history of CAN by reducing CNI exposure whilst avoiding acute rejection. Whilst data will be forthcoming from a number of clinical trials investigating this potential, we discuss early detection of CAN and the rationale for a role for this class of agent.

Chronic allograft nephropathy - a clinical syndrome: Early detection and the potential role of proliferation signal inhibitors / Campistol JM; Boletis IN; Dantal J; de Fijter JW; Hertig A; Neumayer HH; Oyen O; Pascual J; Pohanka E; Ruiz JC; Scolari MP; Stefoni S; Serón D; Sparacino V; Arns W; Chapman JR.. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - ELETTRONICO. - 23:(2009), pp. 769-777. [10.1111/j.1399-0012.2009.01057.x]

Chronic allograft nephropathy - a clinical syndrome: Early detection and the potential role of proliferation signal inhibitors

SCOLARI, MARIA;STEFONI, SERGIO;
2009

Abstract

Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has become established. The proliferation signal inhibitors everolimus and sirolimus have potent immunosuppressive and antiproliferative actions, with the potential to alter the natural history of CAN by reducing CNI exposure whilst avoiding acute rejection. Whilst data will be forthcoming from a number of clinical trials investigating this potential, we discuss early detection of CAN and the rationale for a role for this class of agent.
2009
Chronic allograft nephropathy - a clinical syndrome: Early detection and the potential role of proliferation signal inhibitors / Campistol JM; Boletis IN; Dantal J; de Fijter JW; Hertig A; Neumayer HH; Oyen O; Pascual J; Pohanka E; Ruiz JC; Scolari MP; Stefoni S; Serón D; Sparacino V; Arns W; Chapman JR.. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - ELETTRONICO. - 23:(2009), pp. 769-777. [10.1111/j.1399-0012.2009.01057.x]
Campistol JM; Boletis IN; Dantal J; de Fijter JW; Hertig A; Neumayer HH; Oyen O; Pascual J; Pohanka E; Ruiz JC; Scolari MP; Stefoni S; Serón D; Sparacino V; Arns W; Chapman JR.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/77692
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