Functional hepatic flow and total hepatic flow were determined by non-invasive techniques in 32 patients with cirrhosis and in 32 paired control subjects. Functional hepatic flow was measured by the hepatic clearance of D-sorbitol, while total hepatic flow was determined by pulsed echo-Doppler, as the sum of portal and hepatic arterial blood flow. Functional hepatic flow was significantly reduced in patients with cirrhosis (927±314 vs. 1287±315; p<0.0001), while total hepatic flow was slightly increased (1511±540 vs. 1261±321 in controls; p= 0.028). In control subjects functional hepatic flow significantly correlated with total hepatic flow (r=0.823; p<0.001), while no correlation was observed in cirrhosis. Functional hepatic flow and the difference between total hepatic flow and functional hepatic flow significantly correlated with the Child-Pugh score in patients with cirrhosis. The data obtained in control subjects support the measurement of functional hepatic flow and total hepatic flow by non-invasive techniques. The finding that in cirrhosis functional hepatic flow is significantly decreased, while Doppler-assessed total hepatic flow is preserved or even increased, confirms that a relevant part of blood flowing through the liver is diverted by intrahepatic shunts. The simultaneous assessment of these two parameters by non-invasive techniques may be proposed as a reliable tool for the study of functional shunting of cirrhosis. © 1995.

Zoli M., Magalotti D., Giampaolo B., Gino G., Orlandini C., Grimaldi M., et al. (1995). Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis. JOURNAL OF HEPATOLOGY, 23(2), 129-134 [10.1016/0168-8278(95)80326-2].

Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis

Zoli M.;Marchesini G.;Pisi E.
1995

Abstract

Functional hepatic flow and total hepatic flow were determined by non-invasive techniques in 32 patients with cirrhosis and in 32 paired control subjects. Functional hepatic flow was measured by the hepatic clearance of D-sorbitol, while total hepatic flow was determined by pulsed echo-Doppler, as the sum of portal and hepatic arterial blood flow. Functional hepatic flow was significantly reduced in patients with cirrhosis (927±314 vs. 1287±315; p<0.0001), while total hepatic flow was slightly increased (1511±540 vs. 1261±321 in controls; p= 0.028). In control subjects functional hepatic flow significantly correlated with total hepatic flow (r=0.823; p<0.001), while no correlation was observed in cirrhosis. Functional hepatic flow and the difference between total hepatic flow and functional hepatic flow significantly correlated with the Child-Pugh score in patients with cirrhosis. The data obtained in control subjects support the measurement of functional hepatic flow and total hepatic flow by non-invasive techniques. The finding that in cirrhosis functional hepatic flow is significantly decreased, while Doppler-assessed total hepatic flow is preserved or even increased, confirms that a relevant part of blood flowing through the liver is diverted by intrahepatic shunts. The simultaneous assessment of these two parameters by non-invasive techniques may be proposed as a reliable tool for the study of functional shunting of cirrhosis. © 1995.
1995
Zoli M., Magalotti D., Giampaolo B., Gino G., Orlandini C., Grimaldi M., et al. (1995). Functional hepatic flow and Doppler-assessed total hepatic flow in control subjects and in patients with cirrhosis. JOURNAL OF HEPATOLOGY, 23(2), 129-134 [10.1016/0168-8278(95)80326-2].
Zoli M.; Magalotti D.; Giampaolo B.; Gino G.; Orlandini C.; Grimaldi M.; Marchesini G.; Pisi E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/776532
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