The possible involvement of oxidative damage and antioxidant protection has been suggested in the pathogenesis of dementia, a cognitive disorder whose prevalence increase with aging. In this study we investigated the relationship between dementia and plasma status of antioxidants and oxidative products in oldest-old subjects. Plasma levels of thiobarbituric acid-reactive substances (TBARS), vitamin A, vitamin E, coenzyme Q10 (CoQ10), and serum levels of selenium (Se) and zinc (Zn) were determined in 30 demented patients aged 90 to 107 years in comparison with 32 normal individuals aged 90 to 103 years. Dementia was diagnosed according to DSM-IV criteria. TBARS, vitamin A, vitamin E and CoQ10 were measured by HPLC method. Zn and Se were measured by absorption spectrometry. Vitamins were expressed as lipid-adjusted concentrations. Demented men had higher plasma TBARS (p = 0.037) and lower plasma lipid-adjusted vitamin E (p = 0.043) than normal men, whereas no difference was found for the remaining variables. No difference was found between demented and normal women for the variables of interest. In oldest-old men, but not in women, dementia seems to be associated with an enhanced lipid peroxidation and a reduced vitamin E reserve. It remains to be resolved, however, as to whether this enhanced oxidative stress is a cause or a result of lowered antioxidants.

Oxidative stress and dementia in oldest-old subjects / Ravaglia G.; Forti P.; Maioli F.; Bianchi G.P.; Vettori C.; Nesi B.; Sacchetti L.; Orlanducci P.; Cavalli G.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 33:SUPPL.(2001), pp. 325-331. [10.1016/S0167-4943(01)00156-X]

Oxidative stress and dementia in oldest-old subjects

Ravaglia G.
;
Forti P.;Bianchi G. P.;Cavalli G.
2001

Abstract

The possible involvement of oxidative damage and antioxidant protection has been suggested in the pathogenesis of dementia, a cognitive disorder whose prevalence increase with aging. In this study we investigated the relationship between dementia and plasma status of antioxidants and oxidative products in oldest-old subjects. Plasma levels of thiobarbituric acid-reactive substances (TBARS), vitamin A, vitamin E, coenzyme Q10 (CoQ10), and serum levels of selenium (Se) and zinc (Zn) were determined in 30 demented patients aged 90 to 107 years in comparison with 32 normal individuals aged 90 to 103 years. Dementia was diagnosed according to DSM-IV criteria. TBARS, vitamin A, vitamin E and CoQ10 were measured by HPLC method. Zn and Se were measured by absorption spectrometry. Vitamins were expressed as lipid-adjusted concentrations. Demented men had higher plasma TBARS (p = 0.037) and lower plasma lipid-adjusted vitamin E (p = 0.043) than normal men, whereas no difference was found for the remaining variables. No difference was found between demented and normal women for the variables of interest. In oldest-old men, but not in women, dementia seems to be associated with an enhanced lipid peroxidation and a reduced vitamin E reserve. It remains to be resolved, however, as to whether this enhanced oxidative stress is a cause or a result of lowered antioxidants.
2001
Oxidative stress and dementia in oldest-old subjects / Ravaglia G.; Forti P.; Maioli F.; Bianchi G.P.; Vettori C.; Nesi B.; Sacchetti L.; Orlanducci P.; Cavalli G.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 33:SUPPL.(2001), pp. 325-331. [10.1016/S0167-4943(01)00156-X]
Ravaglia G.; Forti P.; Maioli F.; Bianchi G.P.; Vettori C.; Nesi B.; Sacchetti L.; Orlanducci P.; Cavalli G.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/776137
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact