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Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Nepogodiev D., Bhangu A., Glasbey J.C., Li E., Omar O.M., Simoes J.F., et al. (2020). Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. THE LANCET, 396(10243), 27-38 [10.1016/S0140-6736(20)31182-X].
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Nepogodiev D.;Bhangu A.;Glasbey J. C.;Li E.;Omar O. M.;Simoes J. F.;Abbott T. E.;Alser O.;Arnaud A. P.;Bankhead-Kendall B. K.;Breen K. A.;Cunha M. F.;Davidson G. H.;Di Saverio S.;Gallo G.;Griffiths E. A.;Gujjuri R. R.;Hutchinson P. J.;Kaafarani H. M.;Lederhuber H.;Loffler M. W.;Mashbari H. N.;Minaya-Bravo A.;Morton D. G.;Moszkowicz D.;Pata F.;Tsoulfas G.;Venn M. L.;Cox D.;Roslani A. C.;Alakaloko F.;de Vries J. -P. P.;Aaraj M. A.;Abbott S. J.;Abdalla M. O.;Abdelaal A. S.;Ademuyiwa A. O.;Aherne T. M.;Ali O. M.;Alkadeeki G. Z.;Almeida A. C.;Alrahawy M. M.;Ambler G. K.;Alameer E.;Andreani S. M.;De Andres-Asenjo B.;Antonanzas L. L.;Aoun S. G.;Ashoush F. M.;Augestad K. M.;Avellana R. B.;Ayeni F. A.;Ayorinde J. O.;Babu B. H.;Baig M. M.;Bajomo O. M.;Baker O. J.;Baker M. P.;Baldwin A. J.;Ban V. S.;Baron R. D.;Barranquero A. G.;Barry C. P.;DI Bartolomeo A.;Bass G. A.;Bath M. F.;Batjer H. H.;Beamish A. J.;Belgaumkar A. P.;Bence M. N.;Benson R. A.;Bernal-Sprekelsen J. C.;Bhama A. R.;Bhavaraju A. V.;Biffl W. L.;Blundell C. M.;Boddy A. P.;Borgstein A. B.;Bosanquet D. C.;Bosch K. D.;Bouhuwaish A. E.;Bozkurt M. A.;Brathwaite C. E.;Brown B. C.;Brown O. D.;Brown A. K.;Buarque I. L.;Bueno-Canones A. D.;Bulugma M. R.;Burke J. R.;Byrne M. H.;Cagigal-Ortega E. P.;Callcut R. A.;DI Candido F.;Canova M. E.;Carlos W. J.;Caruana E. J.;Cato L. D.;Catton A. B.;Ceretti A. P.;Chase T. J.;Chiara F. D.;Chowdhury A. H.;Chung E. A.;Cicerchia P. M.;Clough E. C.;Coleman N. L.;Collins C. G.;Collins M. L.;Colonna E. T.;Comini L. V.;Coughlin P. A.;Cruzado L. F. -G.;Davidson B. R.;Davies R. J.;Davies E. J.;Davis N. F.;Dawson B. E.;Dean B. J.;Delgado M. G. -C.;Diaz J. J.;Dickson K. E.;Diez-Alonso M. M.;Dixon J. R.;Doe M. J.;Drake T. D.;Drake F. T.;Duffy J. P.;Dunne D. F.;Dunne N. J.;Duran-Munoz-Cruzado V. M.;Durst A. Z.;Eardley N. J.;Edwards J. G.;Elfallal A. H.;Elfiky M. M.;Elliott J. A.;Emile S. H.;Emslie K. M.;Endorf F. W.;Engel J. L.;Enjuto D. T.;Etchill E. W.;Evans J. P.;Fahey B. A.;Faria C. 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A.;Mazingi D.;Mazzaferro V.;McCanny A.;McKenzie K.;McLarty N.;McPherson I.;Medina E.;Mediratta S.;Medone M.;Mehra G.;Mele S.;Melero-Cortes L.;Mendoza-Moreno F.;Meneghini S.;Mercante G.;Merdrignac A.;Merola S.;Metallidis S.;Michel M.;Migliore M.;Mihanovic J.;Miller D.;Mingoli A.;Minto G.;Mirabella A.;Misra N.;Mitrasinovic S.;Miu V.;Moawad N.;Mochet S.;Modabber A.;Mohammad A.;Mohan M.;Moliner-Sanchez C.;Mongelli F.;Monteleone M.;Montuori M.;Moore R.;Mora-Guzman I.;Morales X.;Morales D.;Morelli L.;Morelli L.;Morgan R.;Morris C.;Mortini P.;Mosca A.;Motter D.;Moug S.;Mukherjee S.;Najdy M.;Nakas A.;Namazov I.;Naredla P.;Nasef E.;Nassa H.;Nath R.;Navarro-Sanchez A.;Nazarian S.;Negri G.;Nehra D.;Neil-Dwyer J.;Neri J.;Newton K.;Nikaj H.;Niquen M.;Nobile S.;Nogueiro J.;Ntirenganya F.;Nugent M.;Nunez J.;Ocana J.;Okechukwu V.;Oliva-Mompean F.;Oliveira A.;Ollat D.;Onos L.;Osagie-Clouard L.;Osman K.;Ottolina J.;Ourieff J.;Outani O.;Oyewole B.;Ozben V.;Pacheco-Sanchez D.;Padilla-Valverde D.;Pai M.;Paiella S.;Paisley S.;Palini G.;Palmeri M.;Panahi P.;Parente A.;Parlanti D.;Parmar C.;Pascual A.;Patel M.;Pathak A.;Patil S.;Pattyn P.;Peckham-Cooper A.;Pedrazzani C.;Pellino G.;Peluso C.;Pereira A.;Pereira-Neves A.;Perez-Diaz M. 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I.;van der Plas W. Y.;Ali I. A. M.;Bakri N. A. C.;Bauset J. C. C.;Abou Chaar M. K.;Marino Cosentino L. M.;Gomez Diaz C. J.;Garcia Galocha J. L.;de Gheldere C. A.;Ataide Gomes G. M.;Beltran de Heredia J.;Blazer III D. G.;Nugent III W. C.;Ali karar A. A.;Borja De Lacy F.;Blas Laina J. L.;Shane Lester M. J.;Liyanage A. S. D.;Al Maadany F. S.;De Marchi J. A.;Ramos-De la Medina A.;Mithany R. H. M.;Sanchez del Pueblo C.;van Ramshorst G. H.;De Salas M. M.;De Souza A. C.;Dolores Del Toro M.;Archer J. E.;Odeh A.;Erridge S.;Salem H. K.;Jones G. P.;Gardner A.;Tripathi S. S.;Gregg A.;Jeganathan R.;Siddique M. H.;Lombardi C. P.;Martin B.;Leo C. A.;Dass D.;Di Franco G.;Jiao L. R.;Mari G. M.;Capitan-Morales L. -C.;Connelly T. M.;Alanbuki A.;De Virgilio A.;Schilling C.;San Miguel Mendez C.;Kulkarni G.;Nizami K.;Walsh S.;Dean H.;Ruiz-Marin M.;Houston R.;Trompetto M.;Chrastek D.;Kouritas V.;Cannoletta M.;Rosato F.;Kaushal M. V.;Costa P. M.;Elkadi H. H.;Johnstone J. R.;Irvine E.;Alvarez M. R.;Corbellini C.;Venkatesan G. S.;Mateo-Sierra O.;Martinez-Perez C.;Serrano Gonzalez J.;Hernandez Bartolome M. A.;Diaz Perez D.;Gutierrez Samaniego M.;Galindo Jara P.;Sharma N.;Smart N. J.;Keller D. S.
2020
Abstract
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Nepogodiev D., Bhangu A., Glasbey J.C., Li E., Omar O.M., Simoes J.F., et al. (2020). Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. THE LANCET, 396(10243), 27-38 [10.1016/S0140-6736(20)31182-X].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/772558
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.