The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity.

Mariacaterina Lianza, Maria Helena Verdan, Jean Paulo de Andrade, Ferruccio Poli, Larissa de Almeida, Leticia Costa-Lotufo, et al. (2020). Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae). JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 31(10), 2135-2145 [10.21577/0103-5053.20200116].

Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)

Mariacaterina Lianza
Resources
;
Ferruccio Poli
Membro del Collaboration Group
;
2020

Abstract

The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity.
2020
Mariacaterina Lianza, Maria Helena Verdan, Jean Paulo de Andrade, Ferruccio Poli, Larissa de Almeida, Leticia Costa-Lotufo, et al. (2020). Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae). JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 31(10), 2135-2145 [10.21577/0103-5053.20200116].
Mariacaterina Lianza; Maria Helena Verdan; Jean Paulo de Andrade; Ferruccio Poli; Larissa de Almeida; Leticia Costa-Lotufo; Álvaro Cunha Neto; Sarah O...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/771915
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