IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists withpro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response,IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathologicalconditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing thetumor microenvironment and promoting cancer initiation and progression. Thus, it orchestratesimmunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recentfindings showed that this cytokine can be directly produced by tumor cells in a positive feedback loopand contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathwaysand senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cellsrefractory to standard therapies needs to be further investigated.

Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

Valerio Gelfo
Conceptualization
;
Donatella Romaniello
Validation
;
Martina Mazzeschi
Writing – Review & Editing
;
Michela Sgarzi
Writing – Review & Editing
;
Giada Grilli
Writing – Review & Editing
;
Beatrice Manzan
Writing – Review & Editing
;
Karim Rihawi
Writing – Review & Editing
;
Mattia Lauriola
Supervision
2020

Abstract

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists withpro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response,IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathologicalconditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing thetumor microenvironment and promoting cancer initiation and progression. Thus, it orchestratesimmunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recentfindings showed that this cytokine can be directly produced by tumor cells in a positive feedback loopand contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathwaysand senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cellsrefractory to standard therapies needs to be further investigated.
Valerio Gelfo; Donatella Romaniello; Martina Mazzeschi; Michela Sgarzi; Giada Grilli; Alessandra Morselli; Beatrice Manzan; Karim Rihawi; Mattia Lauriola
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/769035
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