A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14- dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.0<4,9>]octacos-18-en-2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.

Cabri W, Paissoni, P., Roletto, J., Morra, et al. (2005). Process for the Purification of Tacrolimus.

Process for the Purification of Tacrolimus

Cabri W;
2005

Abstract

A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14- dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.0<4,9>]octacos-18-en-2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.
2005
WO2006048145
Cabri W, Paissoni, P., Roletto, J., Morra, et al. (2005). Process for the Purification of Tacrolimus.
Cabri W; Paissoni; P.; Roletto; J.; Morra; S.; Lazzari.L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/767907
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