This invention relates to a process for preparing a crystalline form of (4S)-11(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3'4':6,7]indolizino[- 1,2-b]quinoline-3,14(4H,12H)-dione, also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing from methanol.

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Cabri W, Giorgi, W., Marzi, M., Marazzi, et al. (2008). New cristalline form of 7-dimethoxymethylcamptothecin.

New cristalline form of 7-dimethoxymethylcamptothecin

Cabri W;
2008

Abstract

This invention relates to a process for preparing a crystalline form of (4S)-11(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3'4':6,7]indolizino[- 1,2-b]quinoline-3,14(4H,12H)-dione, also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing from methanol.
2008
US8269007
Cabri W, Giorgi, W., Marzi, M., Marazzi, et al. (2008). New cristalline form of 7-dimethoxymethylcamptothecin.
Cabri W; Giorgi; W.; Marzi; M.; Marazzi; G.; Badaloni; E.; Armaroli; S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/767841
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