The present application provides an improved process for the preparation of sugammadex. More particularly, the application relates to an improved process for the preparation of 6-per-deoxy-6-per-halo-γ-cyclodextrin and optionally its isolation as a crystalline compound, wherein said halo is bromo or chloro. This application also relates to the use of said crystalline 6-per-deoxy-6-per-halo-γ-cyclodextrin for the preparation of sugammadex which improves overall yield and/or purity of sugammadex.
Zanon, J., Ricci, A., Lahiri, S., et al. (2015). An Improved Process For The Preparation of Sugammadex And Its Intermediates.
An Improved Process For The Preparation of Sugammadex And Its Intermediates
Cabri W
2015
Abstract
The present application provides an improved process for the preparation of sugammadex. More particularly, the application relates to an improved process for the preparation of 6-per-deoxy-6-per-halo-γ-cyclodextrin and optionally its isolation as a crystalline compound, wherein said halo is bromo or chloro. This application also relates to the use of said crystalline 6-per-deoxy-6-per-halo-γ-cyclodextrin for the preparation of sugammadex which improves overall yield and/or purity of sugammadex.File in questo prodotto:
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