The present application provides an improved process for the preparation of sugammadex. More particularly, the application relates to an improved process for the preparation of 6-per-deoxy-6-per-halo-γ-cyclodextrin and optionally its isolation as a crystalline compound, wherein said halo is bromo or chloro. This application also relates to the use of said crystalline 6-per-deoxy-6-per-halo-γ-cyclodextrin for the preparation of sugammadex which improves overall yield and/or purity of sugammadex.

An Improved Process For The Preparation of Sugammadex And Its Intermediates

Cabri W
2015

Abstract

The present application provides an improved process for the preparation of sugammadex. More particularly, the application relates to an improved process for the preparation of 6-per-deoxy-6-per-halo-γ-cyclodextrin and optionally its isolation as a crystalline compound, wherein said halo is bromo or chloro. This application also relates to the use of said crystalline 6-per-deoxy-6-per-halo-γ-cyclodextrin for the preparation of sugammadex which improves overall yield and/or purity of sugammadex.
US10414829
Zanon; J.; Ricci; A.; Lahiri; S.; Cabri W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/767817
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