Objective: To verify if patients with polycystic ovarian syndrome (PCOS), have an increased cardiovascular risk compared with healthy controls. Design: Prospective case-control study. Setting: University-based practice. Patient(s): Twenty eumenorrheic controls (ten lean [group A] and ten overweight [group B]) and 24 PCOS women (14 lean [group C] and ten overweight [group D]). Intervention(s): Cardiovascular risk markers and hormonal parameters were assessed. Main Outcome Measure(s): Androgens, fasting glucose, insulin, leptin, fibrinogen, homocysteine, endothelin-1 and flow-mediated dilatation of the brachial artery were measured to investigate their relationship to weight and to PCOS. Result(s): The brachial artery diameter and the pulsatility index, after the reactive hyperemia, showed in group A the most intense vasodilatation compared with the other groups. Homocysteine levels did not differ among the groups. Endothelin-1 was significantly higher in group A compared with groups B and D. Leptin was significantly lower in groups A and C compared with groups B and D. Insulin resistance was higher in groups B and D. Group A had significantly higher glucose-insulin ratio compared with all of the other groups; group C had significantly higher glucose-insulin ratio only compared with group D. Conclusion(s): Weight and PCOS are two independent variables affecting the endothelial function.

F Mancini, A Cianciosi, G Marchesini Reggiani, F Facchinetti, C Battaglia, D De Aloysio (2009). Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study. FERTILITY AND STERILITY, 91, 537-544 [10.1016/j.fertnstert.2008.03.023].

Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study

MANCINI, FULVIA;MARCHESINI REGGIANI, GIULIO;BATTAGLIA, CESARE;DE ALOYSIO, DOMENICO
2009

Abstract

Objective: To verify if patients with polycystic ovarian syndrome (PCOS), have an increased cardiovascular risk compared with healthy controls. Design: Prospective case-control study. Setting: University-based practice. Patient(s): Twenty eumenorrheic controls (ten lean [group A] and ten overweight [group B]) and 24 PCOS women (14 lean [group C] and ten overweight [group D]). Intervention(s): Cardiovascular risk markers and hormonal parameters were assessed. Main Outcome Measure(s): Androgens, fasting glucose, insulin, leptin, fibrinogen, homocysteine, endothelin-1 and flow-mediated dilatation of the brachial artery were measured to investigate their relationship to weight and to PCOS. Result(s): The brachial artery diameter and the pulsatility index, after the reactive hyperemia, showed in group A the most intense vasodilatation compared with the other groups. Homocysteine levels did not differ among the groups. Endothelin-1 was significantly higher in group A compared with groups B and D. Leptin was significantly lower in groups A and C compared with groups B and D. Insulin resistance was higher in groups B and D. Group A had significantly higher glucose-insulin ratio compared with all of the other groups; group C had significantly higher glucose-insulin ratio only compared with group D. Conclusion(s): Weight and PCOS are two independent variables affecting the endothelial function.
2009
F Mancini, A Cianciosi, G Marchesini Reggiani, F Facchinetti, C Battaglia, D De Aloysio (2009). Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study. FERTILITY AND STERILITY, 91, 537-544 [10.1016/j.fertnstert.2008.03.023].
F Mancini; A Cianciosi; G Marchesini Reggiani; F Facchinetti; C Battaglia; D De Aloysio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/76504
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