Resveratrol for High Blood Pressure: A Total Failure or the Need to Identify the Right Patient?

Resveratrol (3,5,4′-trihydroxystilbene) belongs to a family of polyphenolic compounds known as stilbenes, particularly concentrated in a variety edible fruits, including grapes, ber-ries and nuts.Though the resveratrol amount in foods, its bioavailability after oral administration is usually poor in humans also in consideration of biotransformation phenomena that happen in the liver microsomes and intestine, which lead to less active or completely inactive metabolites. Moreover, its short half-life, labile properties, and rapid metabolism and elimination restrict its potential therapeutic application