Recurrent cytogenetic aberrations, genetic mutations and variable gene expression have been consistently recognized in solid cancers and in leukaemia, including in Myelodysplastic Syndromes (MDS). Besides conventional cytogenetics, the growing accessibility of new techniques has led to a deeper analysis of the molecular significance of genetic variations. Indeed, gene mutations affecting splicing genes, as well as genes implicated in essential signalling pathways, play a pivotal role in MDS physiology and pathophysiology, representing potential new molecular targets for innovative therapeutic strategies.

Follo M.Y., Pellagatti A., Ratti S., Ramazzotti G., Faenza I., Fiume R., et al. (2020). Recent advances in MDS mutation landscape: Splicing and signalling. ADVANCES IN BIOLOGICAL REGULATION, 75, 100673-100679 [10.1016/j.jbior.2019.100673].

Recent advances in MDS mutation landscape: Splicing and signalling

Follo M. Y.
;
Ratti S.;Ramazzotti G.;Faenza I.;Fiume R.;Mongiorgi S.;Manzoli L.;Cocco L.
2020

Abstract

Recurrent cytogenetic aberrations, genetic mutations and variable gene expression have been consistently recognized in solid cancers and in leukaemia, including in Myelodysplastic Syndromes (MDS). Besides conventional cytogenetics, the growing accessibility of new techniques has led to a deeper analysis of the molecular significance of genetic variations. Indeed, gene mutations affecting splicing genes, as well as genes implicated in essential signalling pathways, play a pivotal role in MDS physiology and pathophysiology, representing potential new molecular targets for innovative therapeutic strategies.
2020
Follo M.Y., Pellagatti A., Ratti S., Ramazzotti G., Faenza I., Fiume R., et al. (2020). Recent advances in MDS mutation landscape: Splicing and signalling. ADVANCES IN BIOLOGICAL REGULATION, 75, 100673-100679 [10.1016/j.jbior.2019.100673].
Follo M.Y.; Pellagatti A.; Ratti S.; Ramazzotti G.; Faenza I.; Fiume R.; Mongiorgi S.; Suh P.-G.; McCubrey J.A.; Manzoli L.; Boultwood J.; Cocco L....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/763601
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