Context: Chronic glucocorticoids excess leads to morphological and functional cardiac alterations, a substrate for arrhythmias. Autonomous cortisol secretion (ACS) in adrenal incidentalomas is a model of chronic endogenous hypercortisolism. Objective: To investigate prevalence and incidence of atrial fibrillation (AF) in a large cohort of patients with ACS. Design: Retrospective study. Setting: University hospital. Patients: Patients evaluated between 1990 and 2018 for adrenal incidentalomas (n = 632), without pheochromocytoma, primary aldosteronism, Cushing syndrome, congenital adrenal hyperplasia, and adrenal malignancy. Cortisol after 1-mg dexamethasone suppression test < or > 50 nmol/L defined nonsecreting tumors (NST) (n = 420) and ACS (n = 212), respectively. Intervention: Assessment of AF at baseline (n = 632) and during a median follow-up of 7.7 years retrospectively (NST, n = 249; ACS, n = 108). Comparison with general population. Main outcome measure: Prevalence and incidence of AF. Results: AF prevalence was higher in patients with ACS (8.5%) than NST (3.1%, P = 0.003) and the general population (1.7%; P < 0.001 vs ACS, P = 0.034 vs NST). The age-adjusted rate ratio to the general population was 1.0 for NST and 2.6 for ACS. AF was associated with ACS (odds ratio, 2.40; 95% confidence interval [CI], 1.07-5.39; P = 0.035). The proportion of patients with AF at last evaluation was higher in ACS (20.0%) than NST (11.9%; P = 0.026). ACS showed a higher risk of incident AF than NST (hazard ratio, 2.95; 95% CI, 1.27-6.86; P = 0.012), which was associated with post-dexamethasone cortisol (hazard ratio, 1.15; 95% CI, 1.07-1.24; P < 0.001), independently of known contributing factors. Conclusions: Patients with adrenal incidentalomas and ACS are at risk of AF. Electrocardiogram monitoring may be recommended during follow-up.

Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study / Guido Di Dalmazi, Valentina Vicennati, Carmine Pizzi, Cristina Mosconi, Lorenzo Tucci, Caterina Balacchi, Eugenio Roberto Cosentino, Pasquale Paolisso, Flaminia Fanelli, Alessandra Gambineri, Carla Pelusi, Andrea Repaci, Silvia Garelli, Nazzareno Galiè, Claudio Borghi, Rita Golfieri, Uberto Pagotto. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 105:8(2020), pp. 270-277. [10.1210/clinem/dgaa270]

Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study

Guido Di Dalmazi;Valentina Vicennati;Carmine Pizzi;Cristina Mosconi;Lorenzo Tucci;Caterina Balacchi;Pasquale Paolisso;Flaminia Fanelli;Alessandra Gambineri;Carla Pelusi;Andrea Repaci;Silvia Garelli;Nazzareno Galiè;Claudio Borghi;Rita Golfieri;Uberto Pagotto
2020

Abstract

Context: Chronic glucocorticoids excess leads to morphological and functional cardiac alterations, a substrate for arrhythmias. Autonomous cortisol secretion (ACS) in adrenal incidentalomas is a model of chronic endogenous hypercortisolism. Objective: To investigate prevalence and incidence of atrial fibrillation (AF) in a large cohort of patients with ACS. Design: Retrospective study. Setting: University hospital. Patients: Patients evaluated between 1990 and 2018 for adrenal incidentalomas (n = 632), without pheochromocytoma, primary aldosteronism, Cushing syndrome, congenital adrenal hyperplasia, and adrenal malignancy. Cortisol after 1-mg dexamethasone suppression test < or > 50 nmol/L defined nonsecreting tumors (NST) (n = 420) and ACS (n = 212), respectively. Intervention: Assessment of AF at baseline (n = 632) and during a median follow-up of 7.7 years retrospectively (NST, n = 249; ACS, n = 108). Comparison with general population. Main outcome measure: Prevalence and incidence of AF. Results: AF prevalence was higher in patients with ACS (8.5%) than NST (3.1%, P = 0.003) and the general population (1.7%; P < 0.001 vs ACS, P = 0.034 vs NST). The age-adjusted rate ratio to the general population was 1.0 for NST and 2.6 for ACS. AF was associated with ACS (odds ratio, 2.40; 95% confidence interval [CI], 1.07-5.39; P = 0.035). The proportion of patients with AF at last evaluation was higher in ACS (20.0%) than NST (11.9%; P = 0.026). ACS showed a higher risk of incident AF than NST (hazard ratio, 2.95; 95% CI, 1.27-6.86; P = 0.012), which was associated with post-dexamethasone cortisol (hazard ratio, 1.15; 95% CI, 1.07-1.24; P < 0.001), independently of known contributing factors. Conclusions: Patients with adrenal incidentalomas and ACS are at risk of AF. Electrocardiogram monitoring may be recommended during follow-up.
2020
Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study / Guido Di Dalmazi, Valentina Vicennati, Carmine Pizzi, Cristina Mosconi, Lorenzo Tucci, Caterina Balacchi, Eugenio Roberto Cosentino, Pasquale Paolisso, Flaminia Fanelli, Alessandra Gambineri, Carla Pelusi, Andrea Repaci, Silvia Garelli, Nazzareno Galiè, Claudio Borghi, Rita Golfieri, Uberto Pagotto. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 105:8(2020), pp. 270-277. [10.1210/clinem/dgaa270]
Guido Di Dalmazi, Valentina Vicennati, Carmine Pizzi, Cristina Mosconi, Lorenzo Tucci, Caterina Balacchi, Eugenio Roberto Cosentino, Pasquale Paolisso, Flaminia Fanelli, Alessandra Gambineri, Carla Pelusi, Andrea Repaci, Silvia Garelli, Nazzareno Galiè, Claudio Borghi, Rita Golfieri, Uberto Pagotto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/762688
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