The manipulation of nuclear resources for medical purposes causes considerable concern in occupational exposure. Nevertheless, little information is available for the effects of low-dose irradiations protracted over time. We used oligo-microarrays to identify the genes that are transcriptionally regulated by persistent exposure to extremely low doses of ionizing radiation, in 28 exposed professionals (mean cumulative effective dose ± SD, 19.49±37.59 mSv) compared with a matched sample of non-exposed subjects. We identified 256 modulated genes, from peripheral blood mononuclear cells profiles. The changes in gene expression that we found suggest alternative mechanisms to those involved high-dose studies that may help to define new bio-markers of radiation exposure in the domain of accumulated doses below 25mSv.
E. Morandi, C. Severini, D. Quercioli, S. Perdichizzi, M. G. Mascolo, W. Horn, et al. (2009). Gene expression changes in medical workers exposed to radiation. RADIATION RESEARCH, 172, 500-508 [10.1667/RR1545.1].
Gene expression changes in medical workers exposed to radiation
MORANDI, ELENA;QUERCIOLI, DANIELE;PERDICHIZZI, STEFANIA;MASCOLO, MARIA GRAZIA;HORN, WOLFANGO;VACCARI, MONICA;LODI, VITTORIO;VIOLANTE, FRANCESCO SAVERIO;GRILLI, SANDRO;SILINGARDI, PAOLA;COLACCI, ANNAMARIA
2009
Abstract
The manipulation of nuclear resources for medical purposes causes considerable concern in occupational exposure. Nevertheless, little information is available for the effects of low-dose irradiations protracted over time. We used oligo-microarrays to identify the genes that are transcriptionally regulated by persistent exposure to extremely low doses of ionizing radiation, in 28 exposed professionals (mean cumulative effective dose ± SD, 19.49±37.59 mSv) compared with a matched sample of non-exposed subjects. We identified 256 modulated genes, from peripheral blood mononuclear cells profiles. The changes in gene expression that we found suggest alternative mechanisms to those involved high-dose studies that may help to define new bio-markers of radiation exposure in the domain of accumulated doses below 25mSv.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
