The manipulation of nuclear resources for medical purposes causes considerable concern in occupational exposure. Nevertheless, little information is available for the effects of low-dose irradiations protracted over time. We used oligo-microarrays to identify the genes that are transcriptionally regulated by persistent exposure to extremely low doses of ionizing radiation, in 28 exposed professionals (mean cumulative effective dose ± SD, 19.49±37.59 mSv) compared with a matched sample of non-exposed subjects. We identified 256 modulated genes, from peripheral blood mononuclear cells profiles. The changes in gene expression that we found suggest alternative mechanisms to those involved high-dose studies that may help to define new bio-markers of radiation exposure in the domain of accumulated doses below 25mSv.

Gene expression changes in medical workers exposed to radiation

MORANDI, ELENA;QUERCIOLI, DANIELE;PERDICHIZZI, STEFANIA;MASCOLO, MARIA GRAZIA;HORN, WOLFANGO;VACCARI, MONICA;LODI, VITTORIO;VIOLANTE, FRANCESCO SAVERIO;GRILLI, SANDRO;SILINGARDI, PAOLA;COLACCI, ANNAMARIA
2009

Abstract

The manipulation of nuclear resources for medical purposes causes considerable concern in occupational exposure. Nevertheless, little information is available for the effects of low-dose irradiations protracted over time. We used oligo-microarrays to identify the genes that are transcriptionally regulated by persistent exposure to extremely low doses of ionizing radiation, in 28 exposed professionals (mean cumulative effective dose ± SD, 19.49±37.59 mSv) compared with a matched sample of non-exposed subjects. We identified 256 modulated genes, from peripheral blood mononuclear cells profiles. The changes in gene expression that we found suggest alternative mechanisms to those involved high-dose studies that may help to define new bio-markers of radiation exposure in the domain of accumulated doses below 25mSv.
E. Morandi; C. Severini; D. Quercioli; S. Perdichizzi; M. G. Mascolo; W. Horn; M. Vaccari; M. C. Nucci; V. Lodi; F. S. Violante; C. Bolognesi; S. Grilli; P. Silingardi; A. Colacci
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/76144
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