Stem cells are a potential source for the regeneration of many tissues, including damaged kidneys. The present study describes the adoption of hyaluronic- butyric acid monoesters (HB) to induce expression of nephrogenic genes by mesenchymal cells isolated from human placental membranes. HB at a concentration of 1 mg/mL induces chromatin opening and increases the expression of the observed markers (cadherin 11, CD24, RAR-alpha, stearoyl-CoA desaturase 2, 14-3-3 0, Ewing sarcoma homolog.). These results open new routes toward cell regeneration after kidney injury.
Bianchi F, La Manna G, Cantoni S, Cavallini C, Scolari MP, Ventura C, et al. (2009). Expression of metanephric differentiation markers in human mesenchymal stem cells. [Marker di differenziamento metanefrico espressi in cellule staminali mesenchimanli umane]. GIORNALE ITALIANO DI NEFROLOGIA, S-45, 64-67.
Expression of metanephric differentiation markers in human mesenchymal stem cells. [Marker di differenziamento metanefrico espressi in cellule staminali mesenchimanli umane].
BIANCHI, FRANCESCA;LA MANNA, GAETANO;CANTONI, SILVIA;CAVALLINI, CLAUDIA;SCOLARI, MARIA;VENTURA, CARLO;STEFONI, SERGIO
2009
Abstract
Stem cells are a potential source for the regeneration of many tissues, including damaged kidneys. The present study describes the adoption of hyaluronic- butyric acid monoesters (HB) to induce expression of nephrogenic genes by mesenchymal cells isolated from human placental membranes. HB at a concentration of 1 mg/mL induces chromatin opening and increases the expression of the observed markers (cadherin 11, CD24, RAR-alpha, stearoyl-CoA desaturase 2, 14-3-3 0, Ewing sarcoma homolog.). These results open new routes toward cell regeneration after kidney injury.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
