The fast development of microfluidic devices are helping to realize the possibility of flow control in biological applications e.g. DNA separation or single molecule mapping. However, for the efficient design of such device also a detailed knowledge of the molecules dynamics must be at hand. In this respect, a number of experiments analyzing the relaxation dynamics of DNA both in confined and non confined geometry have been recently presented. In this contribution we propose a numerical study of DNA relaxation in a slitlike geometry obtained via a mesoscopic model both for the solvent and the single chain. We confirm the existence of two relaxation regimes at different extensions as have been observed in a recent experiment by Balducci et al.[1].
RELAXATION DYNAMICS OF CONFINED DNA: A MESOSCALE SIMULATION / De Angelis E.; Chinappi M.. - ELETTRONICO. - (2008), pp. 1-6. (Intervento presentato al convegno 1st European Conference on Microfluidics tenutosi a Bologna nel Dicembre 2008).
RELAXATION DYNAMICS OF CONFINED DNA: A MESOSCALE SIMULATION
DE ANGELIS, ELISABETTA;
2008
Abstract
The fast development of microfluidic devices are helping to realize the possibility of flow control in biological applications e.g. DNA separation or single molecule mapping. However, for the efficient design of such device also a detailed knowledge of the molecules dynamics must be at hand. In this respect, a number of experiments analyzing the relaxation dynamics of DNA both in confined and non confined geometry have been recently presented. In this contribution we propose a numerical study of DNA relaxation in a slitlike geometry obtained via a mesoscopic model both for the solvent and the single chain. We confirm the existence of two relaxation regimes at different extensions as have been observed in a recent experiment by Balducci et al.[1].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
