The fast development of microfluidic devices are helping to realize the possibility of flow control in biological applications e.g. DNA separation or single molecule mapping. However, for the efficient design of such device also a detailed knowledge of the molecules dynamics must be at hand. In this respect, a number of experiments analyzing the relaxation dynamics of DNA both in confined and non confined geometry have been recently presented. In this contribution we propose a numerical study of DNA relaxation in a slitlike geometry obtained via a mesoscopic model both for the solvent and the single chain. We confirm the existence of two relaxation regimes at different extensions as have been observed in a recent experiment by Balducci et al.[1].

RELAXATION DYNAMICS OF CONFINED DNA: A MESOSCALE SIMULATION

DE ANGELIS, ELISABETTA;
2008

Abstract

The fast development of microfluidic devices are helping to realize the possibility of flow control in biological applications e.g. DNA separation or single molecule mapping. However, for the efficient design of such device also a detailed knowledge of the molecules dynamics must be at hand. In this respect, a number of experiments analyzing the relaxation dynamics of DNA both in confined and non confined geometry have been recently presented. In this contribution we propose a numerical study of DNA relaxation in a slitlike geometry obtained via a mesoscopic model both for the solvent and the single chain. We confirm the existence of two relaxation regimes at different extensions as have been observed in a recent experiment by Balducci et al.[1].
Proceedings of the 1st European Conference on Microfluidics
1
6
De Angelis E.; Chinappi M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/75375
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