Control at the nano-scale is a fundamental concern in the production of biomimetic materials, particularly in the case of bone substitutes where the chemical and biological properties are very much size dependent. In fact, as the mineral phase of bone is constituted of carbonated hydroxyapatite (HA) nano-crystals, biomimetic calcium phosphates need to be synthesized with similar nanoscale dimensions, as well as with properties such as low crystallinity, non-stoichiometric composition, crystalline disorder, and presence of carbonate ions in the crystal lattice. Noble metal, especially Au nanoparticles has immense potential for both cancer diagnosis and therapy. In the first case in fact, due to the phenomena of the surface plasmon resonance the adsorption and scattering crosssections of Au nano-particles are significantly superior to the absorbing and fluorescent dyes conventionally used in molecular biology and nanomedicine. In this way conjugation of Au nano-particles to ligands specifically targeted to biomarkers on cancer cells allows molecular specific imaging and detection of cancer. On the other hand, Au nanoparticles efficiently convert the strongly adsorbed light into localized heat, which can be exploited for the selective laser photothermal therapy of cancer. According to the about, metal nanoparticles-HA nanocrystals composites should have tremendous potential in novel methods for therapy of cancer [1] and represent innovative approach to fine-tune cellular response of implanted nano-biomaterials by environmental stimuli ( above all light). In this work Au and Ag nano-particles have been conjugated to HA nanocrystals trough different linkers including phosphonic or bisphosphonic moiety (fig.1 (a)). Alternatively, reverse micelles approach have been used, allowing the water core to be the site of nucleation of these nano-materials. This spatial delimitation has allowed controlling size, shape and structural organization not only of the single components of the inorganic hybrid (that is nano-HA (fig.1(b)) and differently capped metal nano-particles) but also of the resulting composite.

Biomimetic Hydroxyapatite/Metal-Particles Nano-Composites as Potential Candidates for the Photo-Thermal Therapy of Cancer

PALAZZO, BARBARA;FRACASSO, GUIDO;FORESTI, ELISABETTA;ROVERI, NORBERTO
2008

Abstract

Control at the nano-scale is a fundamental concern in the production of biomimetic materials, particularly in the case of bone substitutes where the chemical and biological properties are very much size dependent. In fact, as the mineral phase of bone is constituted of carbonated hydroxyapatite (HA) nano-crystals, biomimetic calcium phosphates need to be synthesized with similar nanoscale dimensions, as well as with properties such as low crystallinity, non-stoichiometric composition, crystalline disorder, and presence of carbonate ions in the crystal lattice. Noble metal, especially Au nanoparticles has immense potential for both cancer diagnosis and therapy. In the first case in fact, due to the phenomena of the surface plasmon resonance the adsorption and scattering crosssections of Au nano-particles are significantly superior to the absorbing and fluorescent dyes conventionally used in molecular biology and nanomedicine. In this way conjugation of Au nano-particles to ligands specifically targeted to biomarkers on cancer cells allows molecular specific imaging and detection of cancer. On the other hand, Au nanoparticles efficiently convert the strongly adsorbed light into localized heat, which can be exploited for the selective laser photothermal therapy of cancer. According to the about, metal nanoparticles-HA nanocrystals composites should have tremendous potential in novel methods for therapy of cancer [1] and represent innovative approach to fine-tune cellular response of implanted nano-biomaterials by environmental stimuli ( above all light). In this work Au and Ag nano-particles have been conjugated to HA nanocrystals trough different linkers including phosphonic or bisphosphonic moiety (fig.1 (a)). Alternatively, reverse micelles approach have been used, allowing the water core to be the site of nucleation of these nano-materials. This spatial delimitation has allowed controlling size, shape and structural organization not only of the single components of the inorganic hybrid (that is nano-HA (fig.1(b)) and differently capped metal nano-particles) but also of the resulting composite.
2nd EuCheMS Chemistry Congress
1
1
B. Palazzo; D. Walsh; A. Patil; G. Fracasso; E. Foresti; N. Roveri
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/73975
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