It is well known that anti-inflammatory drugs are usually carboxylic acids in which the carboxylate group is available for metal-ligand interactions: the formation of such complexes has been hypothesized to play a role to develop and enhance the pharmacological properties of the drug. Surface Enhanced Raman Spectroscopy (SERS) technique with an enhanced up to 106 of the intensity of Raman spectra gives the opportunity to study the mechanism of the action of a drug at concentrations mimicking the physiological condition. In the present paper we present a SERS studies on four non-steroidal anti-inflammatory drugs (NSAIDs) namely the Na salts of Ibuprofen, Tolmetin, Piroxicam and Diclofenac, both alone and in presence of Co++ and Zn++ ions, at concentrations lower than 500 ppm.
Surface enhanced Raman spectroscopy (SERS) investigation on anti-inflammatory drugs interacting with metal ions.
DI FOGGIA, MICHELE;BONORA, SERGIO;MARIS, ASSIMO
2008
Abstract
It is well known that anti-inflammatory drugs are usually carboxylic acids in which the carboxylate group is available for metal-ligand interactions: the formation of such complexes has been hypothesized to play a role to develop and enhance the pharmacological properties of the drug. Surface Enhanced Raman Spectroscopy (SERS) technique with an enhanced up to 106 of the intensity of Raman spectra gives the opportunity to study the mechanism of the action of a drug at concentrations mimicking the physiological condition. In the present paper we present a SERS studies on four non-steroidal anti-inflammatory drugs (NSAIDs) namely the Na salts of Ibuprofen, Tolmetin, Piroxicam and Diclofenac, both alone and in presence of Co++ and Zn++ ions, at concentrations lower than 500 ppm.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
