To diagnose Dry Eye in Fabry disease patients according to the criteria of TFOS DEWS II 2017. Ocular surface parameters, Meibomian glands and tear film profile were studied in order to obtain considerable information about the impact of this lipid storage disorder on the ocular surface. Data showed that Fabry disease causes progressive lipid infiltration and the ocular surface is a target tissue also because of the role of lipids in tear film stability. Our study, the first detailed analysis of ocular surface in these patients, showed reduced TFBUT, Meibomian glands’ drop-out and changes in tear proteins, although not severe ocular symptoms. Thus, a careful evaluation of the ocular surface is fundamental, in order to establish an appropriate management of this incurable but treatable lipid storage disease.
Fariselli, C., Fresina, M., Versura, P., Campos, E.C. (2019). Ocular Surface impairment in Fabry disease. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9), 4713-4713.
Ocular Surface impairment in Fabry disease
Fariselli, C;Fresina, M;Versura, P;Campos, EC
2019
Abstract
To diagnose Dry Eye in Fabry disease patients according to the criteria of TFOS DEWS II 2017. Ocular surface parameters, Meibomian glands and tear film profile were studied in order to obtain considerable information about the impact of this lipid storage disorder on the ocular surface. Data showed that Fabry disease causes progressive lipid infiltration and the ocular surface is a target tissue also because of the role of lipids in tear film stability. Our study, the first detailed analysis of ocular surface in these patients, showed reduced TFBUT, Meibomian glands’ drop-out and changes in tear proteins, although not severe ocular symptoms. Thus, a careful evaluation of the ocular surface is fundamental, in order to establish an appropriate management of this incurable but treatable lipid storage disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
