Machine learning multi-classifiers for peptide classification

In this paper, we study the performance improvement that it is possible to obtain combining classifiers based on different notions (each trained using a different physicochemical property of amino-acids). This multi-classifier has been tested in three problems: HIV-protease; recognition of T-cell epitopes; predictive vaccinology. We propose a multi-classifier that combines a classifier that approaches the problem as a two-class pattern recognition problem and a method based on a one-class classifier. Several classifiers combined with the “sum rule” enables us to obtain an improvement performance over the best results previously published in the literature.