Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. A 65-year-old male presented a monomorphic epitheliotropic intestinal T-cell lymphoma (formerly enteropathy-associated T-cell lymphoma, type II) with HCL not responding to first-line induction with cladribine. The intestinal lymphoma bears the BRAF V600E mutant, which is the molecular hallmark of HCL, being implicated in its pathogenesis. The case is of interest, as it provides the first description of a BRAF V600E-positive intestinal T-cell lymphoma, along with immunohistochemical and molecular demonstration, occurring in concomitance with HCL. A novel digital PCR-base method for HCL disease assessment is also suggested.

Broccoli, A., Bertuzzi, C., Fiorentino, M., Morigi, A., Stefoni, V., Agostinelli, C., et al. (2019). BRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia. ONCOTARGETS AND THERAPY, 12, 4807-4812 [10.2147/OTT.S202061].

BRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia

Broccoli, Alessandro;Bertuzzi, Clara;Fiorentino, Michelangelo;Morigi, Alice;Stefoni, Vittorio;Agostinelli, Claudio;Argnani, Lisa;Cavo, Michele;Zinzani, Pier Luigi
2019

Abstract

Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. A 65-year-old male presented a monomorphic epitheliotropic intestinal T-cell lymphoma (formerly enteropathy-associated T-cell lymphoma, type II) with HCL not responding to first-line induction with cladribine. The intestinal lymphoma bears the BRAF V600E mutant, which is the molecular hallmark of HCL, being implicated in its pathogenesis. The case is of interest, as it provides the first description of a BRAF V600E-positive intestinal T-cell lymphoma, along with immunohistochemical and molecular demonstration, occurring in concomitance with HCL. A novel digital PCR-base method for HCL disease assessment is also suggested.
2019
Broccoli, A., Bertuzzi, C., Fiorentino, M., Morigi, A., Stefoni, V., Agostinelli, C., et al. (2019). BRAF V600E-positive monomorphic epitheliotropic intestinal T-cell lymphoma complicating the course of hairy cell leukemia. ONCOTARGETS AND THERAPY, 12, 4807-4812 [10.2147/OTT.S202061].
Broccoli, Alessandro; Bertuzzi, Clara; Fiorentino, Michelangelo; Morigi, Alice; Stefoni, Vittorio; Agostinelli, Claudio; Argnani, Lisa; Cavo, Michele;...espandi
File in questo prodotto:
File Dimensione Formato  
ott-202061-braf-v600e-positive-monomorphic-epitheliotropic-intestinal-t.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale (CCBYNC)
Dimensione 2.25 MB
Formato Adobe PDF
2.25 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/734628
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact