Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage-in the presence or absence of obstructive coronary atherosclerosis-will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options.

Pries AR, Habazettl H, Ambrosio G, Hansen PR, Kaski JC, Schächinger V, et al. (2008). A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. CARDIOVASCULAR RESEARCH, 80(2), 165-174 [10.1093/cvr/cvn136].

A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings.

BUGIARDINI, RAFFAELE
2008

Abstract

Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage-in the presence or absence of obstructive coronary atherosclerosis-will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options.
2008
Pries AR, Habazettl H, Ambrosio G, Hansen PR, Kaski JC, Schächinger V, et al. (2008). A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. CARDIOVASCULAR RESEARCH, 80(2), 165-174 [10.1093/cvr/cvn136].
Pries AR; Habazettl H; Ambrosio G; Hansen PR; Kaski JC; Schächinger V; Tillmanns H; Vassalli G; Tritto I; Weis M; de Wit C; Bugiardini R....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/72925
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