Ionic cocrystals (ICCs) of LiCl with levodopa and its biological precursors l-tyrosine and l-phenylalanine, namely, l-phe·LiCl·nH2O, l-tyr·LiCl, and l-dopa·LiCl·H2O, were synthesized by mechanochemical mixing of the reactants in the presence of a small quantity of ethanol. In the case of l-dopa, a polymorph of l-dopa·LiCl·H2O was also obtained from solution crystallization. All compounds were investigated by solid state methods, and the structures were determined either from single crystal or from powder diffraction data.

Ionic Cocrystals of Levodopa and Its Biological Precursors l-Tyrosine and l-Phenylalanine with LiCl

Shemchuk O.;Braga D.;Grepioni F.
2019

Abstract

Ionic cocrystals (ICCs) of LiCl with levodopa and its biological precursors l-tyrosine and l-phenylalanine, namely, l-phe·LiCl·nH2O, l-tyr·LiCl, and l-dopa·LiCl·H2O, were synthesized by mechanochemical mixing of the reactants in the presence of a small quantity of ethanol. In the case of l-dopa, a polymorph of l-dopa·LiCl·H2O was also obtained from solution crystallization. All compounds were investigated by solid state methods, and the structures were determined either from single crystal or from powder diffraction data.
Shemchuk O.; Braga D.; Grepioni F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/722596
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