Two co-crystals of melatonin with piperazine and (1,4-diazabicyclo[2.2.2]octane), DABCO, and a hydrated ionic co-crystal with CaCl2 were obtained directly in the solid-state via kneading of the solid mixtures with a few drops of ethanol. The structure of the DABCO co-crystal, mel2·DABCO, was determined by single crystal X-ray diffraction, while those of the piperazine co-crystal, mel2·pip, isomorphous with the DABCO one, and the ionic co-crystal, mel2·CaCl2·2H2O, were determined from powder data. In the case of the ionic co-crystal with CaCl2, solubility measurements indicate that melatonin solubility in water increases by an order of magnitude with respect to the pure substance.

Shemchuk O., Andre V., Duarte M.T., Braga D., Grepioni F. (2019). Mechanochemical preparation of molecular and ionic co-crystals of the hormone melatonin. CRYSTENGCOMM, 21(18), 2949-2954 [10.1039/c9ce00316a].

Mechanochemical preparation of molecular and ionic co-crystals of the hormone melatonin

Shemchuk O.;Duarte M. T.
;
Braga D.;Grepioni F.
2019

Abstract

Two co-crystals of melatonin with piperazine and (1,4-diazabicyclo[2.2.2]octane), DABCO, and a hydrated ionic co-crystal with CaCl2 were obtained directly in the solid-state via kneading of the solid mixtures with a few drops of ethanol. The structure of the DABCO co-crystal, mel2·DABCO, was determined by single crystal X-ray diffraction, while those of the piperazine co-crystal, mel2·pip, isomorphous with the DABCO one, and the ionic co-crystal, mel2·CaCl2·2H2O, were determined from powder data. In the case of the ionic co-crystal with CaCl2, solubility measurements indicate that melatonin solubility in water increases by an order of magnitude with respect to the pure substance.
2019
Shemchuk O., Andre V., Duarte M.T., Braga D., Grepioni F. (2019). Mechanochemical preparation of molecular and ionic co-crystals of the hormone melatonin. CRYSTENGCOMM, 21(18), 2949-2954 [10.1039/c9ce00316a].
Shemchuk O.; Andre V.; Duarte M.T.; Braga D.; Grepioni F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/722579
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