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EnglishOsteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief review analyzes an array of mechanisms that could account for the dramatic bone derangement (bone loss and osteopenia/osteoporosis) during the course of HIV-1 infection.
| Titolo: | Bone alterations during HIV infection | |
| Autore/i: | DE CRIGNIS, ELISA; Cimatti L.; BORDERI, MARCO; GIBELLINI, DAVIDE; RE, MARIA CARLA | |
| Autore/i Unibo: | ||
| Anno: | 2008 | |
| Rivista: | ||
| Abstract: | Osteopenia and osteoporosis are common in HIV-1-infected individuals and represent a challenge in clinical and therapeutic management. Since the mechanisms underlying this degenerative process are largely unsettled and it has not yet been determined whether bone dysfunction is linked to HIV-1-mediated direct and/or indirect effects on osteoblasts/osteoclasts cross-talk regulation, this brief review analyzes an array of mechanisms that could account for the dramatic bone derangement (bone loss and osteopenia/osteoporosis) during the course of HIV-1 infection. | |
| Data prodotto definitivo in UGOV: | 2009-02-19 11:19:40 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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