The authors of this elegant study1 retrospectively reviewed the clinical characteristics of 40 gliomas IDH-wild-type pTERT-mutant astrocytomas (World Health Organization [WHO] grade II [n = 19] and grade III [n = 21]) and compared them to the outcome of 114 IDH-mutant and pTERTwild- type lower grade gliomas (LGG), of 92 IDH-wild-type pTERT-mutant glioblastoma multiforme (GBM), and of 15 IDH-wild-type pTERT-wild-type astrocytomas. The authors showed that IDH-wild-type pTERT-mutant astrocytomas typically present as nonenhancing temporo-insular infiltrative lesions or, in some instances, as gliomatosis cerebri in patients aged >50 yr. Accordingly, although these tumors often display an initial, falsely reassuring, LGG-like appearance, they indeed present a typically aggressive behavior and in the absence of treatment, grow rapidly, and develop GBMlike characteristics.

Commentary: Radiological Characteristics and Natural History of Adult IDH-Wild-Type Astrocytomas With TERT Promoter Mutations

Conti, Alfredo;Tomasello, Francesco
2019

Abstract

The authors of this elegant study1 retrospectively reviewed the clinical characteristics of 40 gliomas IDH-wild-type pTERT-mutant astrocytomas (World Health Organization [WHO] grade II [n = 19] and grade III [n = 21]) and compared them to the outcome of 114 IDH-mutant and pTERTwild- type lower grade gliomas (LGG), of 92 IDH-wild-type pTERT-mutant glioblastoma multiforme (GBM), and of 15 IDH-wild-type pTERT-wild-type astrocytomas. The authors showed that IDH-wild-type pTERT-mutant astrocytomas typically present as nonenhancing temporo-insular infiltrative lesions or, in some instances, as gliomatosis cerebri in patients aged >50 yr. Accordingly, although these tumors often display an initial, falsely reassuring, LGG-like appearance, they indeed present a typically aggressive behavior and in the absence of treatment, grow rapidly, and develop GBMlike characteristics.
Barresi, Valeria; Conti, Alfredo; Tomasello, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/717748
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