Mucinous adenocarcinoma of the prostate is a rare subtype of prostate cancer characterized by the presence of at least 25% of the tumor composed of glands with intracellular mucin.Lung is the second most common extranodal site of metastases after bone. However, solitary lung metastasis from prostate cancer, without osseous or lymphatic involvement, is considered as a rare condition.Locating one single site of recurrence in the early phase of biochemical recurrence is important in order to select the most appropriate therapeutic approach with curative intent, such as metastasis-directed therapy.68-Gallium prostate-specific membrane antigen (68Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) has a high sensitivity for detecting small site of recurrent prostate cancer at low prostate-specific antigen (PSA) levels.In this case report, 68-Ga-PSMA-11 PET/CT detected a solitary mucinous lung metastasis from prostate cancer (negative with 18F-fluorodeoxyglucose PET/ CT and 18F-fluciclovine PET/CT) in a patient with biochemical recurrence after prostatectomy at low PSA levels, leading to metastasis-directed therapy with curative intent. (C) 2018 Elsevier Inc. All rights reserved.
Solitary Mucinous Prostate Adenocarcinoma Lung Metastasis Detected by 68 Ga-PSMA-11 PET/CT / Polverari G.; Ceci F.; Allen-Auerbach M.; Gupta P.; Fishbein M.C.; Reiter R.E.; Lee J.M.; Hope T.A.; Carroll R.M.; Czernin J.; Calais J.. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1558-7673. - STAMPA. - 17:1(2019), pp. e53-e55. [10.1016/j.clgc.2018.09.003]
Solitary Mucinous Prostate Adenocarcinoma Lung Metastasis Detected by 68 Ga-PSMA-11 PET/CT
Polverari G.;Ceci F.;Gupta P.;
2019
Abstract
Mucinous adenocarcinoma of the prostate is a rare subtype of prostate cancer characterized by the presence of at least 25% of the tumor composed of glands with intracellular mucin.Lung is the second most common extranodal site of metastases after bone. However, solitary lung metastasis from prostate cancer, without osseous or lymphatic involvement, is considered as a rare condition.Locating one single site of recurrence in the early phase of biochemical recurrence is important in order to select the most appropriate therapeutic approach with curative intent, such as metastasis-directed therapy.68-Gallium prostate-specific membrane antigen (68Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) has a high sensitivity for detecting small site of recurrent prostate cancer at low prostate-specific antigen (PSA) levels.In this case report, 68-Ga-PSMA-11 PET/CT detected a solitary mucinous lung metastasis from prostate cancer (negative with 18F-fluorodeoxyglucose PET/ CT and 18F-fluciclovine PET/CT) in a patient with biochemical recurrence after prostatectomy at low PSA levels, leading to metastasis-directed therapy with curative intent. (C) 2018 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
