Cholesterol deficiency (CD) is an autosomal recessive defect in Holstein cattle caused by a mutation in the apolipoprotein B gene (APOB). This paper reports the clinical and pathological phenotype of a case of CD in a 5-months-old Holstein calf. Retarded growth, chronic, intermittent diarrhea, stomatitis, hypocholesterolemia and low blood triglycerides concentrations were the most important clinical and ancillary findings. Histopathologically, inflammation of the digestive organs was the most evident sign. Blood from the patient, the dam, sister1, sister2 and semen of the sire were tested for APOB mutation: the calf resulted homozygous, whereas the dam and the sire resulted heterozygous carriers. Both sisters were APOB mutation free. Cholesterol deficiency should be considered in the differential diagnosis of chronic diarrhea and failure to thrive in Holstein calves.
Autosomal Cholesterol Deficiency in a Holstein Calf
Joana Gonçalves Pontes Jacinto;Marilena Bolcato;Arcangelo Gentile;Gianfranco Militerno
2020
Abstract
Cholesterol deficiency (CD) is an autosomal recessive defect in Holstein cattle caused by a mutation in the apolipoprotein B gene (APOB). This paper reports the clinical and pathological phenotype of a case of CD in a 5-months-old Holstein calf. Retarded growth, chronic, intermittent diarrhea, stomatitis, hypocholesterolemia and low blood triglycerides concentrations were the most important clinical and ancillary findings. Histopathologically, inflammation of the digestive organs was the most evident sign. Blood from the patient, the dam, sister1, sister2 and semen of the sire were tested for APOB mutation: the calf resulted homozygous, whereas the dam and the sire resulted heterozygous carriers. Both sisters were APOB mutation free. Cholesterol deficiency should be considered in the differential diagnosis of chronic diarrhea and failure to thrive in Holstein calves.File | Dimensione | Formato | |
---|---|---|---|
PakistanVJ def.pdf
accesso aperto
Tipo:
Versione (PDF) editoriale
Licenza:
Licenza per accesso libero gratuito
Dimensione
410.12 kB
Formato
Adobe PDF
|
410.12 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.