Lithium is a largely used and effective therapy in the treatment of bipolar disorder. Its toxic effects on kidneys are mostly diabetes insipidus, hyperchloremic metabolic acidosis and tubulointerstitial nephritis. Also, a correlation between lithium and minimal change disease has sometimes been described. We report here the case of a patient with severe bipolar disorder on lithium therapy who, without any pre-existing nephropathy, developed nephrotic syndrome and AKI with histopathologic findings pointing to minimal change disease. The patient was treated with symptomatic therapy; the discontinuation of lithium therapy resulted in the remission of AKI and of the nephrotic syndrome, thus suggesting a close relationship between lithium and minimal change disease.

Graziani R, M.M. (2019). Minimal change disease during lithium therapy: case report. GIORNALE ITALIANO DI NEFROLOGIA, 36(4), 1-5.

Minimal change disease during lithium therapy: case report

Cenacchi G
Membro del Collaboration Group
;
Buscaroli A.
Membro del Collaboration Group
2019

Abstract

Lithium is a largely used and effective therapy in the treatment of bipolar disorder. Its toxic effects on kidneys are mostly diabetes insipidus, hyperchloremic metabolic acidosis and tubulointerstitial nephritis. Also, a correlation between lithium and minimal change disease has sometimes been described. We report here the case of a patient with severe bipolar disorder on lithium therapy who, without any pre-existing nephropathy, developed nephrotic syndrome and AKI with histopathologic findings pointing to minimal change disease. The patient was treated with symptomatic therapy; the discontinuation of lithium therapy resulted in the remission of AKI and of the nephrotic syndrome, thus suggesting a close relationship between lithium and minimal change disease.
2019
Graziani R, M.M. (2019). Minimal change disease during lithium therapy: case report. GIORNALE ITALIANO DI NEFROLOGIA, 36(4), 1-5.
Graziani R, Monti M, Sejdiu B, Gozzetti F, Martelli D, Tampieri E, Isola E, Zanchelli F, Briganti M, Cenacchi G, Fabbrizio B, Buscaroli A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/714293
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